GAPDH Cancer Research Results

GAPDH, Glyceraldehyde-3-phosphate dehydrogenase: Click to Expand ⟱

Source:

Type: gene

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a housekeeping gene that encodes a protein involved in glycolysis, a metabolic pathway that converts glucose into energy. GAPDH is a crucial enzyme in the glycolytic pathway, and its expression is often used as a control gene in molecular biology experiments.
GAPDH has been shown to be overexpressed in various types of tumors, including breast, lung, colon, and prostate cancer.
Cancer cells often exhibit increased glycolysis, even in the presence of oxygen, a phenomenon known as the Warburg effect. GAPDH overexpression can contribute to this increased glycolysis.

CRC, Colorectal Cancer: Click to Expand ⟱

Colorectal cancer is a broader term that encompasses both colon and rectal cancer.

Scientific Papers found: Click to Expand⟱

2178-

itraC,

Itraconazole inhibits tumor growth via CEBPB-mediated glycolysis in colorectal cancer

in-vivo,

CRC,

HCT116

xenograft model in tumor-bearing mice

TumCG↓, Glycolysis↓, CEBPB?, ENO1↓, LDHA↓, PKM2↓, GAPDH↓, ECAR↓, OCR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Mitochondria & Bioenergetics ⓘ

OCR↓, 1,

Core Metabolism/Glycolysis ⓘ

ECAR↓, 1, ENO1↓, 1, GAPDH↓, 1, Glycolysis↓, 1, LDHA↓, 1, PKM2↓, 1,

Proliferation, Differentiation & Cell State ⓘ

CEBPB?, 1, TumCG↓, 1,
Total Targets: 9

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: GAPDH, Glyceraldehyde-3-phosphate dehydrogenase

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells