DNMT1 Cancer Research Results

DNMT1, DNA (cytosine-5-)-methyltransferase 1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
DNMT1 overexpression in various cancer types.
DNA (cytosine-5-)-methyltransferase 1, commonly referred to as DNMT1, is an enzyme that plays a crucial role in the maintenance of DNA methylation patterns.
Increased DNMT1 activity can promote tumorigenesis by facilitating the accumulation of methylation changes that drive cancer progression.
Is frequently overexpressed in a variety of cancers, including breast, colorectal, lung, prostate, and hematological malignancies. This overexpression is often associated with hypermethylation of tumor suppressor genes, leading to their silencing and contributing to tumorigenesis.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
4671- CUR,    Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy
- in-vitro, CRC, NA
CSCs↓, TumCG↓, ChemoSen↑, Wnt↓, β-catenin/ZEB1↓, Shh↓, NOTCH↓, DNMT1↓, STAT3↓, NF-kB↓, EGFR↓, IGFR↓, TumCCA↓, cl‑PARP↑, BAX↑, ECM/TCF↓,
443- CUR,    Reduced Caudal Type Homeobox 2 (CDX2) Promoter Methylation Is Associated with Curcumin’s Suppressive Effects on Epithelial-Mesenchymal Transition in Colorectal Cancer Cells
- in-vitro, CRC, SW480
DNMT1↓, DNMT3A↓, N-cadherin↓, Vim↓, Wnt↓, Snail↓, Twist↓, β-catenin/ZEB1↓, E-cadherin↑, EMT↓, CDX2↓,
2915- LT,    Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells
- in-vitro, Colon, HT29 - in-vitro, CRC, SNU-407 - in-vitro, Nor, FHC
DNMTs↓, TET1↑, NRF2↑, HDAC↓, tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, ROS↓, GSS↑, Catalase↑, HO-1↑, DNMT1↓, DNMT3A↓, TET1↑, TET3↑, TET2↓, P53↑, P21↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSS↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,  

Cell Death ⓘ

BAX↑, 2,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Transcription & Epigenetics ⓘ

TET3↑, 1,   tumCV↓, 1,  

DNA Damage & Repair ⓘ

DNMT1↓, 3,   DNMT3A↓, 2,   DNMTs↓, 1,   P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CDX2↓, 1,   CSCs↓, 1,   EMT↓, 1,   HDAC↓, 1,   IGFR↓, 1,   NOTCH↓, 1,   Shh↓, 1,   STAT3↓, 1,   TumCG↓, 1,   Wnt↓, 2,  

Migration ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   Snail↓, 1,   TET1↑, 2,   Twist↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature ⓘ

ECM/TCF↓, 1,   EGFR↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   TET2↓, 1,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  
Total Targets: 41

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: DNMT1, DNA (cytosine-5-)-methyltransferase 1
2 Curcumin
1 Luteolin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:85  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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