Akt Cancer Research Results

Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
5278- 3BP,    The effect of 3-bromopyruvate on human colorectal cancer cells is dependent on glucose concentration but not hexokinase II expression
- in-vitro, CRC, HCT116 - in-vitro, CRC, Caco-2 - in-vitro, CRC, SW48
ATP↓, TumCD↑, selectivity↑, toxicity↓, OS↑, HK2?, Cyt‑c↑, eff↑, p‑Akt↑,
6672- Deg,    Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice
- vitro+vivo, CRC, COLO205 - in-vitro, CRC, HCT116
Akt↑, AntiTum↑, IL8↓, p‑IKKα↓, NF-kB↓, TumCD↑, Apoptosis↑, cFLIP↓, Bcl-2↓, Bcl-xL↓, TumVol↓,
4638- HT,    Hydroxytyrosol induces apoptosis in human colon cancer cells through ROS generation
- in-vitro, CRC, DLD1 - NA, NA, 1-
selectivity↑, ROS↑, Akt↑, FOXO3↓, Apoptosis↑,
1135- Selenate,    Selenate induces epithelial-mesenchymal transition in a colorectal carcinoma cell line by AKT activation
- in-vitro, CRC, DLD1
EMT↑, Akt↑, Twist↑, Vim↑, E-cadherin↓,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

HK2?, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 3,   p‑Akt↑, 1,   Apoptosis↑, 2,   Bcl-2↓, 1,   Bcl-xL↓, 1,   cFLIP↓, 1,   Cyt‑c↑, 1,   TumCD↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↑, 1,   FOXO3↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↓, 1,   Twist↑, 1,   Vim↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

p‑IKKα↓, 1,   IL8↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,   selectivity↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   OS↑, 1,   toxicity↓, 1,   TumVol↓, 1,  
Total Targets: 25

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
1 3-bromopyruvate
1 Deguelin
1 HydroxyTyrosol
1 Selenate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:4  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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