Casp3 Cancer Research Results

Casp3, CPP32, Cysteinyl aspartate specific proteinase-3: Click to Expand ⟱

Source:

Type:

Also known as CP32.
Cysteinyl aspartate specific proteinase-3 (Caspase-3) is a common key protein in the apoptosis and pyroptosis pathways, and when activated, the expression level of tumor suppressor gene Gasdermin E (GSDME) determines the mechanism of tumor cell death.
As a key protein of apoptosis, caspase-3 can also cleave GSDME and induce pyroptosis. Loss of caspase activity is an important cause of tumor progression.
Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to shrink tumors. Crucial for apoptotic function are executioner caspases, most notably caspase-3, that proteolyze a variety of proteins, inducing cell death. Paradoxically, overexpression of procaspase-3 (PC-3), the low-activity zymogen precursor to caspase-3, has been reported in a variety of cancer types. Until recently, this counterintuitive overexpression of a pro-apoptotic protein in cancer has been puzzling. Recent studies suggest subapoptotic caspase-3 activity may promote oncogenic transformation, a possible explanation for the enigmatic overexpression of PC-3. Herein, the overexpression of PC-3 in cancer and its mechanistic basis is reviewed; collectively, the data suggest the potential for exploitation of PC-3 overexpression with PC-3 activators as a targeted anticancer strategy.
Caspase 3 is the main effector caspase and has a key role in apoptosis. In many types of cancer, including breast, lung, and colon cancer, caspase-3 expression is reduced or absent.
On the other hand, some studies have shown that high levels of caspase-3 expression can be associated with a better prognosis in certain types of cancer, such as breast cancer. This suggests that caspase-3 may play a role in the elimination of cancer cells, and that therapies aimed at activating caspase-3 may be effective in treating certain types of cancer.
Procaspase-3 is a apoptotic marker protein.
Prognostic significance:
• High Cas3 expression: Associated with good prognosis and increased sensitivity to chemotherapy in breast, gastric, lung, and pancreatic cancers.
• Low Cas3 expression: Linked to poor prognosis and increased risk of recurrence in colorectal, hepatocellular carcinoma, ovarian, and prostate cancers.

CRC, Colorectal Cancer: Click to Expand ⟱

Colorectal cancer is a broader term that encompasses both colon and rectal cancer.

Scientific Papers found: Click to Expand⟱

4774-

5-FU,

TQ,

CoQ10,

Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation

in-vitro,

CRC,

AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,

5143-

AgNPs,

Thermal Co-reduction engineered silver nanoparticles induce oxidative cell damage in human colon cancer cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

in-vitro,

CRC,

HCT116

28.11 μg/ml.

ROS↑, lipid-P↑, GSH↓, MMP↓, Casp3↑, Apoptosis↑, TumCCA↑,

1351-

And,

MEL,

Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids

in-vitro,

CRC,

T84

in-vitro,

CRC,

COLO205

in-vitro,

CRC,

HT-29

in-vitro,

CRC,

DLD1

eff↑, Ki-67↓, Casp3↑, ER Stress↑, ROS↑, BAX↑, XBP-1↑, CHOP↑, eff↑,

2634-

Api,

Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells

in-vitro,

CRC,

HCT116

TumCG↓, TumCCA↑, MMP↓, ROS↑, Ca+2↑, ER Stress↑, mtDam↑, CHOP↑, DR5↑, cl‑BID↑, BAX↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, Apoptosis↑,

206-

Api,

Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress

in-vitro,

Lung,

H1299

 20 uM

in-vitro,

Lung,

H460

in-vitro,

Lung,

A549

 40 uM

in-vitro,

CRC,

HCT116

in-vitro,

Melanoma,

A375

in-vitro,

Lung,

H2030

in-vitro,

CRC,

SW480

Glycolysis↓, lactateProd↓, PGK1↓, ALDOA↓, GLUT1↓, ENO1↓, ATP↓, Casp9↑, Casp3↑, cl‑PARP↑, PI3K/Akt↓, HK1↓, HK2↓, ROS↑, Apoptosis↑, eff↓, NADPH↓, PPP↓,

4806-

ASTX,

Astaxanthin's Impact on Colorectal Cancer: Examining Apoptosis, Antioxidant Enzymes, and Gene Expression

in-vitro,

CRC,

HCT116

 25, 50, 100, and 150 μM for a duration of 24 hours

BAX↑, Casp3↑, Apoptosis↑, Bcl-2↓, MDA↓, ROS↓, SOD↑, Catalase↑, GPx↑, antiOx↑, TumCG↓, TumCP↓,

2477-

Ba,

Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells

in-vitro,

CRC,

T24/HTB-9

TumCG↓, TumCCA↑, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, p‑Akt↓, Bcl-2↓, BAX↑, Bax:Bcl2↑, 12LOX↓,

5539-

BBM,

Berbamine suppresses cell viability and induces apoptosis in colorectal cancer via activating p53-dependent apoptotic signaling pathway

vitro+vivo,

CRC,

SW480

tumCV↓, TumCCA↑, MMP↓, P53↑, Casp3↑, Casp9↑, BAX↑, PARP↑, Bcl-2↓, TumVol↑,

5547-

BBM,

Berbamine exerts anticancer effects on human colon cancer cells via induction of autophagy and apoptosis, inhibition of cell migration and MEK/ERK signalling pathway

in-vitro,

CRC,

HT29

tumCV↓, selectivity↑, Casp3↑, Casp9↑, Bax:Bcl2↑, ATG5↑, Beclin-1↑, TumCP↓, MEK↓, ERK↓,

5176-

BBR,

Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice

vitro+vivo,

CRC,

HCT116

mice

in-vitro,

CRC,

SW480

in-vitro,

CRC,

LoVo

TumVol↓, Ki-67↓, COX2↓, AMPK↑, mTOR↓, NF-kB↓, cycD1/CCND1↓, survivin↓, P53↑, cl‑Casp3↑, TumCP↓, Inflam↓, COX2↓, ACC↑,

2719-

BetA,

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential

in-vitro,

CRC,

T24/HTB-9

30 μg/mL BA for 48 h

in-vitro,

Bladder,

UMUC3

33.2 μg/mL

in-vitro,

Bladder,

5637

 28.5 μg/mL

TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,

2734-

BetA,

Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer

in-vitro,

CRC,

HCT116

6.441 µg/mL (14.15 µM)

in-vitro,

CRC,

SW480

1.67 µg/mL (3.670 µM)

tumCV↓, HSP70/HSPA5⇅, ROS↑, cl‑Casp3↑, mt-Apoptosis↑, Dose↝,

5678-

BML,

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy

in-vivo,

CRC,

investigated using different CRC cell lines, a zebrafish model, and a xenograft mouse model.

AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, Endoglin↑, Casp3↑, Casp8↑, Casp9↑, ATG5↑, Beclin-1↑, p62↑, PARP↑,

5685-

BML,

The Therapeutic Effects of Bromelain against Colorectal Cancer: A Systematic Review

Review,

CRC,

TumCG↓, TumMeta↓, ROS⇅, Bcl-2↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, P53↑,

2047-

Buty,

Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells

in-vitro,

CRC,

T24/HTB-9

0-10mM

in-vitro,

Nor,

SV-HUC-1

in-vitro,

Bladder,

5637

in-vivo,

NA,

200 mg/kg/day, i.g., n = 5

mice

HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,

5877-

CA,

Carnosol induces apoptosis through generation of ROS and inactivation of STAT3 signaling in human colon cancer HCT116 cells

in-vitro,

CRC,

HCT116

tumCV↓, Apoptosis↑, Casp9↑, Casp3↑, cl‑PARP↑, BAX↑, Bcl-2↓, Bcl-xL↓, P53↓, MDM2↓, ROS↑, eff↓, STAT3↓, survivin↓, cycD1/CCND1↓,

5866-

CA,

Carnosic acid inhibits STAT3 signaling and induces apoptosis through generation of ROS in human colon cancer HCT116 cells

in-vitro,

CRC,

HCT116

in-vitro,

Colon,

SW480

in-vitro,

Colon,

HT29

tumCV↓, Apoptosis↑, P53↑, BAX↑, MDM2↓, Bcl-2↓, Bcl-xL↓, Casp9↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cycD1/CCND1↓, CycD3↓, ROS↑, eff↓, eff↑,

5198-

CAP,

Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines

in-vitro,

CRC,

LoVo

in-vitro,

CRC,

Colo320

tumCV↓, DNAdam↑, Apoptosis↑, ROS↑, MMP↑, Casp3↑, chemoPv↑,

1517-

CAP,

Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)

in-vitro,

Bladder,

TSGH8301

in-vitro,

CRC,

T24/HTB-9

ENOX2↓, TumCCA↑, ERK↓, p‑FAK↓, p‑pax↓, TumCMig↓, EMT↓, SIRT1↓, Dose∅, ROS↑, MMP↓, Bcl-2↓, Bak↑, cl‑PARP↑, Casp3↑, SIRT1↓, ac‑P53↑, BIM↑, p‑RB1↓, cycD1/CCND1↓, Dose∅, β-catenin/ZEB1↓, N-cadherin↓, E-cadherin↑,

2804-

CHr,

Rad,

Gamma-Irradiated Chrysin Improves Anticancer Activity in HT-29 Colon Cancer Cells Through Mitochondria-Related Pathway

in-vitro,

CRC,

HT29

RadioS↑, ROS↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑,

447-

CUR,

OXA,

Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-β/Smad2/3 signaling pathway

vitro+vivo,

CRC,

HCT116

1, 2, 4, 8, 16, 32 and 64 μM, 48 h; 60 mg/kg, 3 weeks

4uM(Cur)+10uM(OXA)

p‑p65↓, Bcl-2↓, Casp3↑, EMT↓, p‑SMAD2↓, p‑SMAD3↓, N-cadherin↓, TGF-β↓, E-cadherin↑, TumVol↓, TumCMig↓,

444-

CUR,

Cisplatin,

LncRNA KCNQ1OT1 is a key factor in the reversal effect of curcumin on cisplatin resistance in the colorectal cancer cells

vitro+vivo,

CRC,

HCT8

10 μM, 48 h; 1 g/kg/week, 42 days

TumVol↓, Apoptosis↑, Bcl-2↓, Cyt‑c↑, BAX↑, cl‑Casp3↑, cl‑PARP1↑, miR-497↑, KCNQ1OT1↓,

1878-

DCA,

5-FU,

Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer

in-vitro,

CRC,

LS174T

57mM

in-vitro,

CRC,

LoVo

29mM

in-vitro,

CRC,

SW-620

38mM

in-vitro,

CRC,

HT-29

47mM

tumCV↓, eff↑, PDKs↓, lactateProd↓, Glycolysis↓, mitResp↑, TumCCA↑, Bcl-2↓, BAX↑, Casp3↑,

811-

GAR,

Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells

in-vitro,

CRC,

HT-29

mPGES-1↓, Hif1a↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, Casp3↑, TumCP↓, PGE2↓,

823-

GAR,

Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

in-vitro,

CRC,

HCT116

Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,

841-

Gra,

The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach

in-vitro,

CRC,

HT-29

1.62ug/ml@48hr

in-vitro,

Nor,

CCD841

32.51μg/ml@48 h

normal human colon cells

PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,

857-

Gra,

The Value of Caspase-3 after the Application of Annona muricata Leaf Extract in COLO-205 Colorectal Cancer Cell Line

in-vitro,

CRC,

COLO205

Casp3↑, tumCV↓,

848-

Gra,

AgNPs,

Synthesis, Characterization and Evaluation of Antioxidant and Cytotoxic Potential of Annona muricata Root Extract-derived Biogenic Silver Nanoparticles

in-vitro,

CRC,

HCT116

ROS↑, PUMA↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑,

1657-

HCAs,

Anticancer Activity of Sinapic Acid by Inducing Apoptosis in HT-29 Human Colon Cancer Cell Line 2023

in-vitro,

CRC,

HT-29

200 μM

317.5 μM for 24 hours

cl‑Casp3↑, BAX↑, cl‑PARP↑, γH2AX↑, Cyt‑c↑,

2177-

itraC,

Itraconazole improves survival outcomes in patients with colon cancer by inducing autophagic cell death and inhibiting transketolase expression

Study,

Colon,

present study analyzed extensive data from patients diagnosed with colon cancer using itraconazole between January 2011 and December 2015

in-vitro,

CRC,

COLO205

in-vitro,

CRC,

HCT116

OS↑, tumCV↓, Casp3↑, TumCCA↑, HH↓, TumAuto↑, LC3B↑, p62↑, TKT↓,

1064-

LT,

Cisplatin,

Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells

vitro+vivo,

Lung,

LNM35

25-200μM

intraperitoneal injection (20mg/kg/day for 18days)

in-vitro,

CRC,

HT-29

in-vitro,

Liver,

HepG2

in-vitro,

BC,

MCF-7

in-vitro,

BC,

MDA-MB-231

Casp3↑, Casp7↑, HDAC↓,

2915-

LT,

Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells

in-vitro,

Colon,

HT29

30 μM

in-vitro,

CRC,

SNU-407

30 μM

in-vitro,

Nor,

FHC

65 μM

DNMTs↓, TET1↑, NRF2↑, HDAC↓, tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, ROS↓, GSS↑, Catalase↑, HO-1↑, DNMT1↓, DNMT3A↓, TET1↑, TET3↑, TET2↓, P53↑, P21↑,

4534-

MAG,

Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells

in-vitro,

Liver,

HepG2

in-vitro,

CRC,

COLO205

AntiCan↑, Apoptosis↑, selectivity↑, Ca+2↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,

4531-

MAG,

Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway

in-vitro,

CRC,

HCT116

Apoptosis↑, DNAdam↑, Casp3↑, cl‑PARP↑, p‑AMPK↑, Bcl-2↓, P53↑, BAX↑, Cyt‑c↑, TumCMig↓, TumCI↓,

775-

Mg,

The Supplement of Magnesium Element to Inhibit Colorectal Tumor Cells

vitro+vivo,

CRC,

DLD1

30mM

After 72 h treatment, the cell viability decreased by 71.7% in the 30 mM Mg2+ group

TumCCA↑, Apoptosis↑, Casp3↑, TumCG↓,

2070-

PB,

Phenylbutyrate-induced apoptosis is associated with inactivation of NF-kappaB IN HT-29 colon cancer cells

in-vitro,

CRC,

HT-29

TumCG↓, Apoptosis↑, MMP↓, Casp3↑, PARP↓, NF-kB↓, eff↑,

2078-

PB,

Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response

in-vitro,

CRC,

HCT116

0-20mM

p38↑, ER Stress↑, Casp3↑, Casp7↑, TumCD↑, Apoptosis↑, TumCP↑, HSP27↓,

1678-

PBG,

5-FU,

sericin,

In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/AKT/mTOR pathway

in-vitro,

CRC,

Caco-2

in-vivo,

NA,

105 in bred- albino mice

PI3K↓, Akt↓, mTOR↓, TumCP↓, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, ROS↓, FOXO1↑, *toxicity∅, eff↑,

4787-

QC,

Quercetin: A Phytochemical with Pro-Apoptotic Effects in Colon Cancer Cells

Review,

CRC,

Inflam↓, AntiCan↑, Apoptosis↑, MMP↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, NF-kB↓, IL6↓, IL1β↓, *antiOx↑, *lipid-P↓, *ROS↓, MAPK↓, JAK↓, STAT↓, PI3K↓, Akt↓, chemoP↑, ROS⇅, DNAdam↑, ChemoSen↝,

1307-

SANG,

Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway

in-vitro,

CRC,

HT-29

Apoptosis↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑,

1388-

Sco,

Scoulerine promotes cell viability reduction and apoptosis by activating ROS-dependent endoplasmic reticulum stress in colorectal cancer cells

in-vitro,

CRC,

tumCV↓, Apoptosis↑, Casp3↑, Casp7↑, BAX↑, Bcl-2↓, ROS↑, GSH↓, SOD↓, ER Stress↑, GRP78/BiP↑, CHOP↑, eff↓,

2231-

SK,

Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways

in-vitro,

CRC,

SNU-407

3 µM after 48 h

Apoptosis↑, ER Stress↑, PERK↑, eIF2α↑, CHOP↑, mt-Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, ERK↑, JNK↑, p38↓,

2228-

SK,

Shikonin induced Apoptosis Mediated by Endoplasmic Reticulum Stress in Colorectal Cancer Cells

in-vitro,

CRC,

HCT116

0.25, 0.5, 1, 1.5, 2, 2.5 and 3 μM

in-vitro,

CRC,

HCT15

in-vivo,

NA,

 intraperitoneal injection (3 mg/kg, 3 times per week

mouse

Apoptosis↑, Bcl-2↓, Casp3↑, Casp9↑, cl‑PARP↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, CHOP↑, JNK↑, eff↓, ER Stress↑, ROS↑, TumCG↓,

3047-

SK,

Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL-6/STAT3 signaling pathway

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

SW48

TumCG↓, p‑STAT3↓, ADAM17↓, Apoptosis↑, Casp3↑, cl‑PARP↑, cycD1/CCND1↓, cycE/CCNE↓, TumCCA↑, JAK1?, p‑JAK1↓, p‑JAK2↓, p‑eIF2α↑, eff↓, ROS↑, IL6↓,

5339-

TFdiG,

Pre-treated theaflavin-3,3′-digallate has a higher inhibitory effect on the HCT116 cell line

in-vitro,

CRC,

HCT116

eff↑, TumCCA↑, Inflam↓, COX2↓, iNOS↓, P53↑, P21↑, cl‑Casp3↑,

3413-

TQ,

Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase

in-vitro,

CRC,

HCT116

tumCV↓, Apoptosis↓, BAX↑, Bcl-2↓, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, STAT3↓, survivin↓, cMyc↓, cycD1/CCND1↓, p27↑, P21↑, EGFR↓, ROS↑,

3397-

TQ,

Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer

Review,

CRC,

6-112uM (table 1)

ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,

1823-

VitK2,

VitK3,

Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells

in-vitro,

CRC,

in-vivo,

NA,

mice

TumCP↓, TumCCA↑, Casp3↑,

Showing Research Papers: 1 to 48 of 48

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 48

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 2, Catalase↑, 1, GPx↑, 1, GSTA1↑, 1, lipid-P↓, 1, MDA↓, 1, ROS↓, 2, SOD↑, 1,

Migration ⓘ

MMP13↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, IL1β↓, 1, Inflam↓, 1, PGE2↓, 1,

Drug Metabolism & Resistance ⓘ

BioAv↝, 1, eff↓, 1, Half-Life↝, 1,

Functional Outcomes ⓘ

hepatoP↑, 1, toxicity↓, 1, toxicity∅, 1,
Total Targets: 19

Scientific Paper Hit Count for: Casp3, CPP32, Cysteinyl aspartate specific proteinase-3

3 5-fluorouracil
3 Thymoquinone
3 Graviola
3 Shikonin
2 Silver-NanoParticles
2 Apigenin (mainly Parsley)
2 Berbamine
2 Betulinic acid
2 Bromelain
2 Carnosic acid
2 Capsaicin
2 Curcumin
2 Cisplatin
2 Garcinol
2 Luteolin
2 Magnolol
2 Phenylbutyrate
1 Coenzyme Q10
1 Andrographis
1 Melatonin
1 Astaxanthin
1 Baicalein
1 Berberine
1 Butyrate
1 Chrysin
1 Radiotherapy/Radiation
1 Oxaliplatin
1 Dichloroacetate
1 Hydroxycinnamic-acid
1 itraconazole
1 Magnesium
1 Propolis -bee glue
1 sericin
1 Quercetin
1 Sanguinarine
1 Scoulerine
1 Aflavin-3,3′-digallate
1 Vitamin K2
1 VitK3,menadione

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:42  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

Casp3 Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Migration ⓘ

Immune & Inflammatory Signaling ⓘ

Drug Metabolism & Resistance ⓘ

Functional Outcomes ⓘ

Home Page