LC3s Cancer Research Results

LC3s, Autophagosome Proteins: Click to Expand ⟱

Source:

Type:

LC3s (MAP1-LC3A, B and C) are structural proteins of autophagosomal membranes, widely used as biomarkers of autophagy. Whether these three LC3 proteins have a similar biological role in autophagy remains obscure.
Protumorigenic: In many cases, especially in advanced cancers, increased autophagy (reflected by high LC3 levels) can support tumor growth by providing nutrients and promoting cell survival under stress conditions.
Antitumorigenic: Conversely, in early-stage tumors or in response to certain therapies, autophagy can act as a tumor suppressor by preventing the accumulation of damaged organelles and proteins.

CRC, Colorectal Cancer: Click to Expand ⟱

Colorectal cancer is a broader term that encompasses both colon and rectal cancer.

Scientific Papers found: Click to Expand⟱

1018-

SSE,

Selenite-induced autophagy antagonizes apoptosis in colorectal cancer cells in vitro and in vivo

vitro+vivo,

CRC,

HCT116

injected i.p. with sodium selenite (2 mg/kg/day

vitro+vivo,

CRC,

SW480

TumAuto↑, LC3s↑, TumW↓, Weight∅, Beclin-1↑, p62↓, ROS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

ROS↑, 1,

Autophagy & Lysosomes ⓘ

Beclin-1↑, 1, LC3s↑, 1, p62↓, 1, TumAuto↑, 1,

Functional Outcomes ⓘ

TumW↓, 1, Weight∅, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: LC3s, Autophagosome Proteins

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells