miR-29b Cancer Research Results

miR-29b, miR-29b: Click to Expand ⟱
Source:
Type:
miR-29b is a microRNA that has been extensively studied for its role in cancer. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to the 3' untranslated region (3' UTR) of target mRNAs, leading to their degradation or inhibition of translation.

miR-29b has been found to act as a tumor suppressor in various types of cancer, including lung, breast, colon, and liver cancer. It targets several genes involved in cell proliferation, apoptosis, and metastasis, including:
-Collagen genes (COL1A1, COL1A2, COL3A1), which are involved in tumor cell invasion and metastasis.
-Cell cycle regulators (CDK6, CCND1), which promote cell proliferation.
-Anti-apoptotic genes (MCL1, BCL2), which inhibit programmed cell death.
-Epithelial-to-mesenchymal transition (EMT) regulators (ZEB1, ZEB2), which promote tumor cell migration and invasion.

Downregulation of miR-29b has been observed in various cancers, and this downregulation is often associated with poor prognosis and aggressive tumor behavior. Conversely, overexpression of miR-29b has been shown to inhibit tumor growth, induce apoptosis, and suppress metastasis in cancer cells.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
4812- ASTX,    Astaxanthin suppresses the metastasis of colon cancer by inhibiting the MYC-mediated downregulation of microRNA-29a-3p and microRNA-200a
- in-vitro, CRC, HCT116
miR-29b↑, miR-200b↑, MMP2↓, Zeb1↓, EMT↓, Apoptosis↑, ERK↓, MAPK↓, PI3K↓, Akt↓, MMPs↓, TumMeta↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   ERK↓, 1,   PI3K↓, 1,  

Migration ⓘ

miR-200b↑, 1,   miR-29b↑, 1,   MMP2↓, 1,   MMPs↓, 1,   TumMeta↓, 1,   Zeb1↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-29b, miR-29b
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:658  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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