APAF1 Cancer Research Results
APAF1, Apoptotic Protease Activating Factor 1: Click to Expand ⟱
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| Type: protein |
APAF1 (Apoptotic Protease Activating Factor 1) is a protein that plays a crucial role in the regulation of apoptosis, or programmed cell death. APAF1 is a key component of the intrinsic pathway of apoptosis, which is activated in response to cellular stress or damage.
Downregulated in: breast, lung, prostate, colon (with poor prognosis)
APAF1 activators have been developed and are being tested in preclinical and clinical studies.
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CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
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Scientific Papers found: Click to Expand⟱
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vitro+vivo, |
CRC, |
SW-620 |
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in-vitro, |
CRC, |
LoVo |
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ChemoSen↑, TumCP↓, TumCI↓, TumCMig↓, APAF1↑, Casp9↑, Casp3↑, TumCCA↑, cycD1/CCND1↑, CDK2↑, CDK4↑, PI3K↓, Akt↓,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Cell Death(tgid=5) ⓘ
Akt↓, 1, APAF1↑, 1, Casp3↑, 1, Casp9↑, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
CDK2↑, 1, CDK4↑, 1, cycD1/CCND1↑, 1, TumCCA↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
PI3K↓, 1,
Migration(tgid=13) ⓘ
TumCI↓, 1, TumCMig↓, 1, TumCP↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
ChemoSen↑, 1,
Total Targets: 13
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: APAF1, Apoptotic Protease Activating Factor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:6 Cells:% prod#:% Target#:807 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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