AntiCan Cancer Research Results

AntiCan, Anticancer Effect: Click to Expand ⟱
Source:
Type: general indicator
Anticancer Effect


CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
4774- 5-FU,  TQ,  CoQ10,    Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation
- in-vitro, CRC, NA
AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27/CDKN1B↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,
4403- AgNPs,    Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment
- in-vitro, GBM, U251 - in-vitro, GBM, U87MG - in-vitro, GBM, GL26 - in-vitro, Cerv, HeLa - in-vitro, CRC, RKO
AntiCan↑, eff↑, EPR↑, selectivity↑, ROS↑, Casp↑, Apoptosis↑, DNAdam↑, tumCV↓, eff↑,
4412- AgNPs,    Biosynthesis and characterization of silver nanoparticles from Asplenium dalhousiae and their potential biological properties
- in-vitro, CRC, HCT116 - in-vitro, Melanoma, A2780S
Bacteria↓, antiOx↑, AntiCan↑, eff↑,
4561- AgNPs,  VitC,    Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts
- in-vitro, CRC, HCT116 - in-vitro, Nor, HEK293
NRF2↑, TumCCA↑, ROS↑, selectivity↑, *AntiViral↑, *toxicity↝, ETC↓, MMP↓, DNAdam↑, Apoptosis↑, lipid-P↑, other↝, UPR↑, *GRP78/BiP↑, *p‑PERK↑, *cl‑eIF2α↑, *CHOP/DDIT3↑, *JNK↑, Hif1a↓, AntiCan↑, *toxicity↓, eff↑,
6496- BCP,    β-Caryophyllene Induces Apoptosis and Inhibits Angiogenesis in Colorectal Cancer Models
- vitro+vivo, CRC, HCT116 - in-vitro, Nor, HUVECs
angioG↓, VEGF↓, TumVol↓, Apoptosis↑, HSP60/HSPD1↓, HTRA↓, survivin↓, XIAP↓, P21↑, *toxicity↓, *neuroP↑, *ROS↓, *COX2↓, *Inflam↓, *cardioP↑, AntiCan↑, ChemoSen↑, ROS↑, MMP↑, Bax:Bcl2↑, TumCG↓,
5678- BML,    Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy
- in-vivo, CRC, NA
AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, Endoglin↑, Casp3↑, Casp8↑, Casp9↑, ATG5↑, Beclin-1↑, p62↑, PARP↑,
5706- Brut,    Bergamot juice extract inhibits proliferation by inducing apoptosis in human colon cancer cells
- in-vitro, CRC, HT29
TumCG↓, MAPK↓, TumCCA↑, Apoptosis↑, ROS↑, DNAdam↑, AntiCan↑,
5733- Buty,  VitB3,    Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
- in-vivo, CRC, NA
GutMicro↑, HCAR2↑, AntiCan↑, Inflam↓, IL18↑,
7411- CS,    Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line
- in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HCT116
AntiCan↑, chemoPv↑, Apoptosis↑, TumCI↓, Casp↑, p16↑, P21↑, TumCCA↑, ROS↓, eff↓, TumCD↑, TumCG↓, cellSen↑, *ROS↓,
4673- CUR,    Curcumin and colorectal cancer: An update and current perspective on this natural medicine
- Review, CRC, NA
AntiCan↑, GutMicro↝,
7193- EGb 761,  5-FU,    Ginkgo biloba extract 761 enhances 5-fluorouracil chemosensitivity in colorectal cancer cells through regulation of high mobility group-box 3 expression
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
*antiOx↑, AntiCan↑, ChemoSen↑, selectivity↑, EMT↓, E-cadherin↑, Vim↓, HMGB1↓, other↝, chemoPv↑,
7013- Fuc,    Fucoidan-based nanoparticles for colorectal cancer therapy: Mechanisms and preclinical insights
- Review, CRC, NA
*Inflam↓, *antiOx↑, AntiCan↑, BioAv↑, Apoptosis↑, angioG↓, Imm↝, ChemoSen↑, chemoP↑,
6565- Ger,    Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo-205 cells by inducing apoptosis, DNA damage and cell cycle arrest
- in-vitro, CRC, COLO205
AntiCan↑, mt-Apoptosis↑, BAX↑, Bcl-2↓, DNAdam↑, TumCCA↑,
4523- HNK,  MAG,  BA,    Honokiol-Magnolol-Baicalin Possesses Synergistic Anticancer Potential and Enhances the Efficacy of Anti-PD-1 Immunotherapy in Colorectal Cancer by Triggering GSDME-Dependent Pyroptosis
- in-vitro, CRC, HCT116 - in-vitro, CRC, LoVo - in-vivo, CRC, HCT116
AntiCan↑, eff↑, TumCP↓, TumCCA↓, cycD1/CCND1↓, Pyro↑, Apoptosis↑, cl‑GSDME↑, Bcl-2↓, Cyt‑c↑, Casp9↑, TumCG↓,
4534- MAG,    Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells
- in-vitro, Liver, HepG2 - in-vitro, CRC, COLO205
AntiCan↑, Apoptosis↑, selectivity↑, Ca+2↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,
4536- MAG,    Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis
- in-vitro, Liver, HepG2 - in-vivo, CRC, COLO205
AntiCan↑, selectivity↑, TumCCA↑, P21↑, Apoptosis↑,
4926- PEITC,    PEITC inhibits the invasion and migration of colorectal cancer cells by blocking TGF-β-induced EMT
- in-vitro, CRC, SW48
TumCI↓, TumCMig↓, EMT↓, Smad1↓, AntiCan↑, Snail↓, Slug↓, Zeb1↓, ZEB2↓, TGF-β1↓, eff↑, E-cadherin↑, N-cadherin↓, Vim↓,
1016- PI,    Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, DLD1
β-catenin/ZEB1↓, Wnt↓, TumCP↓, TumCMig↓, *antiOx↑, *Inflam↓, *hepatoP↑, *neuroP↑, *Bacteria↓, *memory↑, AntiCan↑, NF-kB↓, cFos↓, ATF2↓, CREB↓,
4787- QC,    Quercetin: A Phytochemical with Pro-Apoptotic Effects in Colon Cancer Cells
- Review, CRC, NA
Inflam↓, AntiCan↑, Apoptosis↑, MMP↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, NF-kB↓, IL6↓, IL1β↓, *antiOx↑, *lipid-P↓, *ROS↓, MAPK↓, JAK↓, STAT↓, PI3K↓, Akt↓, chemoP↑, ROS⇅, DNAdam↑, ChemoSen↝,
1694- Se,    Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer
- Analysis, CRC, NA
AntiCan↑, selenoP↓,
4725- Se,    Targeting the Nrf2-Prx1 Pathway with Selenium to Enhance the Efficacy and Selectivity of Cancer Therapy
- in-vitro, Lung, A549 - in-vitro, CRC, HT29
AntiCan↑, NRF2↓, Prx↓, ChemoSen↑, *Prx↑, *NRF2↑,
4470- SeNPs,  Chit,    Synthesis and cytotoxic activities of selenium nanoparticles incorporated nano-chitosan
- in-vitro, CRC, HCT116 - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7
Dose↝, AntiCan↑, eff↑,
1697- SSE,  Calc,    Calcium intake may explain the reduction of colorectal cancer odds by dietary selenium - a case-control study in Poland
- Human, CRC, NA
Risk↓, Risk↓, Dose∅, AntiCan↑,
5017- UA,    Ursolic acid disturbs ROS homeostasis and regulates survival-associated gene expression to induce apoptosis in intestinal cancer cells
- in-vitro, Cerv, INT-407 - in-vitro, CRC, HCT116
AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, TumCMig↓, CTNNB1↓, Twist↓, Bcl-2↓, survivin↓, NF-kB↓, Sp1/3/4↓, BAX↑, P21↑, P53↑, eff↓, TumCMig↓,

Showing Research Papers: 1 to 24 of 24

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 24

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

HSP60/HSPD1↓, 1,   HTRA↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 1,   lipid-P↑, 1,   NRF2↓, 1,   NRF2↑, 1,   Prx↓, 1,   ROS↓, 1,   ROS↑, 7,   ROS⇅, 1,   selenoP↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ETC↓, 1,   MMP↓, 2,   MMP↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CREB↓, 1,   LDHA↓, 1,   PDH↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis↑, 13,   mt-Apoptosis↑, 1,   ATF2↓, 1,   BAX↑, 4,   Bax:Bcl2↑, 1,   Bcl-2↓, 6,   Casp↑, 2,   Casp3↑, 4,   Casp8↑, 2,   Casp9↑, 4,   Cyt‑c↑, 3,   cl‑GSDME↑, 1,   MAPK↓, 2,   p27/CDKN1B↑, 1,   Pyro↑, 1,   survivin↓, 3,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,   HCAR2↑, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 5,   p16↑, 1,   P53↑, 2,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   P21↑, 5,   TumCCA↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,   CTNNB1↓, 1,   EMT↓, 2,   mTOR↓, 1,   PI3K↓, 2,   PTEN↑, 1,   STAT↓, 1,   TumCG↓, 6,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   E-cadherin↑, 2,   N-cadherin↓, 1,   Slug↓, 1,   Smad1↓, 1,   Snail↓, 1,   TGF-β1↓, 1,   TumCI↓, 2,   TumCMig↓, 4,   TumCP↓, 2,   Twist↓, 1,   Vim↓, 2,   Zeb1↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Endoglin↑, 1,   EPR↑, 1,   Hif1a↓, 2,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

cellSen↑, 1,   HCAR2↑, 1,   HMGB1↓, 1,   IL18↑, 1,   IL1β↓, 1,   IL6↓, 1,   Imm↝, 1,   Inflam↓, 2,   JAK↓, 1,   NF-kB↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 4,   ChemoSen↝, 1,   Dose↝, 1,   Dose∅, 1,   eff↓, 2,   eff↑, 8,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,   GutMicro↝, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 25,   chemoP↑, 2,   chemoPv↑, 2,   Risk↓, 2,   TumVol↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 110

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4,   lipid-P↓, 1,   NRF2↑, 1,   Prx↑, 1,   ROS↓, 3,  

Cell Death(tgid=5) ⓘ

JNK↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   cl‑eIF2α↑, 1,   GRP78/BiP↑, 1,   p‑PERK↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   Inflam↓, 3,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 2,   toxicity↓, 2,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 1,  
Total Targets: 20

Scientific Paper Hit Count for: AntiCan, Anticancer Effect
3 Silver-NanoParticles
3 Magnolol
2 5-fluorouracil
2 Selenium
1 Thymoquinone
1 Coenzyme Q10
1 Vitamin C (Ascorbic Acid)
1 Beta-Caryophyllene
1 Bromelain
1 Bruteridin(bergamot juice)
1 Butyrate
1 Vitamin B3,Niacin
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Curcumin
1 Ginkgo biloba-EGb 761
1 Fucoidan
1 Geraniol
1 Honokiol
1 Baicalin
1 Phenethyl isothiocyanate
1 Piperine
1 Quercetin
1 Selenium NanoParticles
1 chitosan
1 Selenite (Sodium)
1 Calcium
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:813  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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