Necroptosis Cancer Research Results

Necroptosis, Necroptosis: Click to Expand ⟱

Source:

Type: type of cell death

Necroptosis, is a form of programmed cell death that is regulated by the cell's own mechanisms. It is a form of cell death that is mediated by specific signaling pathways, including the RIP1-RIP3-MLKL pathway. Necroptosis is characterized by the activation of specific enzymes, such as RIP1 and RIP3, which lead to the formation of a necroptotic complex that ultimately causes cell death.

Necroptosis expression can be elevated in certain types of cancer, it can also be reduced in other types of cancer.

CRC, Colorectal Cancer: Click to Expand ⟱

Colorectal cancer is a broader term that encompasses both colon and rectal cancer.

Scientific Papers found: Click to Expand⟱

2184-

SK,

Cisplatin,

PKM2 Inhibitor Shikonin Overcomes the Cisplatin Resistance in Bladder Cancer by Inducing Necroptosis

in-vitro,

CRC,

T24/HTB-9

PKM2↓, ChemoSen↑, Necroptosis↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

PKM2↓, 1,

Cell Death ⓘ

Necroptosis↑, 1,

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Necroptosis, Necroptosis

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells