GCLC Cancer Research Results

GCLC, Glutamate-Cysteine Ligase, Catalytic Subunit: Click to Expand ⟱
Source:
Type:
The GCLC gene (Glutamate-Cysteine Ligase, Catalytic Subunit) is a key regulator of glutathione synthesis, and its expression has been studied in various types of cancer.
GCLC gene has been found to be:
Amplified in 15% of breast cancer cases
Mutated in 5% of lung cancer cases
Deleted in 10% of prostate cancer cases
Methylated in 20% of colorectal cancer cases
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
1009- And,  5-FU,    Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer
- in-vivo, CRC, HCT116 - in-vitro, CRC, SW480
ChemoSen↑, Casp9↑, Ferroptosis↑, Wnt/(β-catenin)↓, FTL↑, TP53↑, ACSL5↑, GCLC↑, GCLM↑, SAT1↑, STEAP3↑, ACSL5↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GCLC↑, 1,   GCLM↑, 1,  

Metal & Cofactor Biology ⓘ

FTL↑, 1,   STEAP3↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACSL5↑, 2,   SAT1↑, 1,  

Cell Death ⓘ

Casp9↑, 1,   Ferroptosis↑, 1,  

DNA Damage & Repair ⓘ

TP53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Wnt/(β-catenin)↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,  

Clinical Biomarkers ⓘ

TP53↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GCLC, Glutamate-Cysteine Ligase, Catalytic Subunit
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:966  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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