Endoglin Cancer Research Results

Endoglin, CD105: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Endoglin, also known as CD105, is a glycoprotein that is primarily expressed on the surface of endothelial cells and is involved in angiogenesis, the process of new blood vessel formation. Elevated levels of endoglin have been associated with poor prognosis in various cancers, including breast, colorectal, and lung cancers. Its expression levels may serve as a biomarker for tumor progression and response to therapy.

Many solid tumors such as breast, lung, colon, and pancreatic cancers exhibit high CD105 expression in their peritumoral and intratumoral vasculature. This is often used as a surrogate marker for the extent of angiogenesis.

CD105 (endoglin) is a pivotal protein in the regulation of angiogenesis. In cancer, its high expression—especially on the endothelial cells of tumor vasculature—is often associated with increased angiogenic activity, aggressive tumor behavior, and poorer prognosis.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
5678- BML,    Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy
- in-vivo, CRC, NA
AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, Endoglin↑, Casp3↑, Casp8↑, Casp9↑, ATG5↑, Beclin-1↑, p62↑, PARP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp3↑, 1,   Casp8↑, 1,   Casp9↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 1,   p62↑, 1,  

DNA Damage & Repair ⓘ

PARP↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Angiogenesis & Vasculature ⓘ

Endoglin↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Endoglin, CD105
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:97  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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