HMGB1 Cancer Research Results

HMGB1, High Mobility Group Box 1: Click to Expand ⟱
Source:
Type:
HMGB1 is a nuclear protein that plays key roles in DNA architecture and regulation of transcription; however, when released extracellularly it can act as a damage-associated molecular pattern (DAMP), influencing immune responses and affecting tumor progression.

Overexpression of HMGB1, particularly when associated with increased extracellular release, is frequently correlated with enhanced tumor aggressiveness, metastasis, and poorer survival across several cancer types including breast, colorectal, lung, ovarian, and pancreatic cancers.
• Its critical involvement in inflammation and immune modulation makes HMGB1 an attractive candidate for targeted therapeutic intervention as well as a potential prognostic marker.
Sepsis, Sepsis: Click to Expand ⟱
Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. This initial stage of sepsis is followed by suppression of the immune system. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion.
Scientific Papers found: Click to Expand⟱
2393- Cela,    Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- in-vivo, Sepsis, NA - in-vitro, Nor, RAW264.7
OS↑, PKM2↓, Glycolysis↓, Warburg↓, Inflam↓, HMGB1↓, ALAT↓, AST↓, TNF-α↓, IL1β↓, IL6↓,
2508- H2,    Molecular hydrogen is a promising therapeutic agent for pulmonary disease
- Review, Var, NA - Review, Sepsis, NA
*ROS↓, eff↝, *Inflam↓, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *MPO↑, *ASK1↓, *NADPH↓, *Sepsis↓, *HMGB1↓, ROS↑, NLRP3↑, GSDMD↑, chemoP↑, eff↑,
3349- QC,    HMGB1_Protein_Expression">Quercetin Exerted Protective Effects in a Rat Model of Sepsis via Inhibition of Reactive Oxygen Species (ROS) and Downregulation of High Mobility Group Box 1 (HMGB1) Protein Expression
- in-vivo, Sepsis, NA
*Sepsis↓, *ROS↓, *SOD↑, *Catalase↑, *HMGB1↓, *Inflam↓, *TAC↑,
2354- SK,    PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
- in-vivo, Sepsis, NA
PKM2↓, *PKM2↓, *IL1β↓, *IL18↓, *HMGB1↓, *Casp1↓, *NLRP3↓, *AIM2↓, *p‑eIF2α↓, *Sepsis↓,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   Glycolysis↓, 1,   PKM2↓, 2,   Warburg↓, 1,  

Cell Death ⓘ

GSDMD↑, 1,  

Immune & Inflammatory Signaling ⓘ

HMGB1↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Protein Aggregation ⓘ

NLRP3↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   eff↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   OS↑, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 2,   HO-1↑, 1,   MPO↑, 1,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 2,   TAC↑, 1,  

Core Metabolism/Glycolysis ⓘ

NADPH↓, 1,   PKM2↓, 1,  

Cell Death ⓘ

ASK1↓, 1,   Casp1↓, 1,  

Protein Folding & ER Stress ⓘ

p‑eIF2α↓, 1,  

Immune & Inflammatory Signaling ⓘ

AIM2↓, 1,   HMGB1↓, 3,   IL18↓, 1,   IL1β↓, 1,   Inflam↓, 2,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 3,  
Total Targets: 19

Scientific Paper Hit Count for: HMGB1, High Mobility Group Box 1
1 Celastrol
1 Hydrogen Gas
1 Quercetin
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:65  Cells:%  prod#:%  Target#:1059  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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