ATF4 Cancer Research Results

ATF4, Activating Transcription Factor 4: Click to Expand ⟱
Source:
Type: protein
ATF4 (Activating Transcription Factor 4) is a protein that plays a crucial role in various cellular processes, including stress response, cell growth, and differentiation.
ATF4 is overexpressed in several types of cancer, including breast, lung, colon, and pancreatic cancer. The overexpression of ATF4 can contribute to cancer cell growth, survival, and resistance to chemotherapy.
ATF4 promotes cancer cell growth by regulating the expression of genes involved in cell proliferation, angiogenesis, and metastasis. It also inhibits apoptosis (programmed cell death) by regulating the expression of anti-apoptotic genes.
Sepsis, Sepsis: Click to Expand ⟱
Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. This initial stage of sepsis is followed by suppression of the immune system. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion.
Scientific Papers found: Click to Expand⟱
3024- RosA,    rmMANF prevents sepsis-associated lung injury via inhibiting endoplasmic reticulum stress-induced ferroptosis in mice
- in-vivo, Sepsis, NA
*Ferroptosis↓, *GRP78/BiP↓, *PERK↓, *ATF4↓, *Sepsis↓, *GSH↑, *SOD↑, *Catalase↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   Ferroptosis↓, 1,   GSH↑, 1,   SOD↑, 1,  

Cell Death ⓘ

Ferroptosis↓, 1,  

Protein Folding & ER Stress ⓘ

GRP78/BiP↓, 1,   PERK↓, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↓, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 9

Scientific Paper Hit Count for: ATF4, Activating Transcription Factor 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:65  Cells:%  prod#:%  Target#:730  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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