DNMT1 Cancer Research Results

DNMT1, DNA (cytosine-5-)-methyltransferase 1: Click to Expand ⟱

Source: CGL-Driver Genes

Type: Oncogene

DNMT1 overexpression in various cancer types.
DNA (cytosine-5-)-methyltransferase 1, commonly referred to as DNMT1, is an enzyme that plays a crucial role in the maintenance of DNA methylation patterns.
Increased DNMT1 activity can promote tumorigenesis by facilitating the accumulation of methylation changes that drive cancer progression.
Is frequently overexpressed in a variety of cancers, including breast, colorectal, lung, prostate, and hematological malignancies. This overexpression is often associated with hypermethylation of tumor suppressor genes, leading to their silencing and contributing to tumorigenesis.

Sepsis, Sepsis: Click to Expand ⟱

Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. This initial stage of sepsis is followed by suppression of the immune system. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion.

Scientific Papers found: Click to Expand⟱

4234-

H2,

Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice

in-vivo,

Sepsis,

 septic mice.

*cognitive↑, *DNMT1↓, *DNMT3A↓, *BDNF↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

DNA Damage & Repair ⓘ

DNMT1↓, 1, DNMT3A↓, 1,

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,

Functional Outcomes ⓘ

cognitive↑, 1,
Total Targets: 4

Scientific Paper Hit Count for: DNMT1, DNA (cytosine-5-)-methyltransferase 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells