DNMT3A Cancer Research Results

DNMT3A, DNA (cytosine-5-)-methyltransferase 3 alpha: Click to Expand ⟱

Source: CGL-Driver Genes

Type: Oncogene

DNA (cytosine-5-)-methyltransferase 3 alpha, commonly referred to as DNMT3A, is an enzyme that plays a crucial role in the process of DNA methylation, which is an important mechanism for regulating gene expression and maintaining genomic stability.
The expression levels of DNMT3A and the presence of mutations can serve as prognostic markers in certain cancers.
In some cancers, DNMT3A is overexpressed, leading to increased DNA methylation of tumor suppressor genes.

Biological Consequences of DNMT3A Loss
-Epigenetic drift rather than uniform hypomethylation
-Persistence of stem-like transcriptional programs
-Increased self-renewal of hematopoietic stem cells
-Impaired differentiation with preserved viability

Importantly, DNMT3A loss does not strongly increase proliferation on its own—it increases clonal persistence and evolutionary potential.

Sepsis, Sepsis: Click to Expand ⟱

Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. This initial stage of sepsis is followed by suppression of the immune system. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion.

Scientific Papers found: Click to Expand⟱

4234-

H2,

Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice

in-vivo,

Sepsis,

 septic mice.

*cognitive↑, *DNMT1↓, *DNMT3A↓, *BDNF↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

DNA Damage & Repair ⓘ

DNMT1↓, 1, DNMT3A↓, 1,

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,

Functional Outcomes ⓘ

cognitive↑, 1,
Total Targets: 4

Scientific Paper Hit Count for: DNMT3A, DNA (cytosine-5-)-methyltransferase 3 alpha

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells