MMP9:TIMP1 Cancer Research Results

MMP9:TIMP1, MMP-9/TIMP-1 ratio: Click to Expand ⟱
Source:
Type:
The balance between matrix metalloproteinase-9 (MMP-9) and its inhibitor, tissue inhibitor of metalloproteinases-1 (TIMP-1), is critical in regulating extracellular matrix remodeling.
A high MMP-9/TIMP-1 ratio—reflecting either elevated MMP-9 levels, reduced TIMP-1 levels, or both—has been consistently associated with increased invasiveness, metastasis, and poorer prognosis in multiple cancer types including breast, lung, and colorectal cancers.

• This ratio is being explored as a potential biomarker for tumor aggressiveness and may aid in patient stratification, treatment decision-making, and monitoring therapeutic responses.

For sepsis:
Although both MMP-9 and TIMP-1 levels were found equally elevated in sepsis, a decrease in the MMP-9/TIMP-1 ratio is significantly associated with severity and mortality.
Sepsis, Sepsis: Click to Expand ⟱
Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. This initial stage of sepsis is followed by suppression of the immune system. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion.
Scientific Papers found: Click to Expand⟱
1220- VitC,  VitB1/Thiamine,    The Effect of Thiamine, Ascorbic Acid, and the Combination of Them on the Levels of Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Matrix Metalloproteinase-1 (TIMP-1) in Sepsis Patients
- Trial, Sepsis, NA
MMP9:TIMP1↑, Sepsis↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

MMP9:TIMP1↑, 1,  

Infection & Microbiome ⓘ

Sepsis↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MMP9:TIMP1, MMP-9/TIMP-1 ratio
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:65  Cells:%  prod#:%  Target#:1049  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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