PPARα Cancer Research Results

PPARα, Peroxisome Proliferator-Activated Receptor Alpha: Click to Expand ⟱

Source:

Type:

• PPARα
– Regulates fatty acid oxidation, lipid metabolism, and energy homeostasis.
– Expressed primarily in liver, heart, kidney, and muscle, PPARα activation induces genes involved in β-oxidation and lipid transport.
– It is also involved in modulating inflammatory responses, which may indirectly affect cellular proliferation and survival.

– Expression and activation in cancers can vary:
– In some liver cancers, PPARα expression or activity may be altered, reflecting its central role in hepatic metabolism.
– Overactivation has been associated with liver proliferation in rodent models; however, species differences exist regarding the carcinogenic potential of PPARα agonists.
– Outside the liver, PPARα’s role is less defined, but its regulation of inflammation and lipid metabolism may influence tumor metabolism and microenvironment.

Sepsis, Sepsis: Click to Expand ⟱

Sepsis is a potentially life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs. This initial stage of sepsis is followed by suppression of the immune system. Common signs and symptoms include fever, increased heart rate, increased breathing rate, and confusion.

Scientific Papers found: Click to Expand⟱

4235-

H2,

PPARα contributes to the therapeutic effect of hydrogen gas against sepsis-associated encephalopathy with the regulation to the CREB-BDNF signaling pathway and hippocampal neuron plasticity-related gene expression

in-vivo,

Sepsis,

C57BL/6 J mice

*PPARα↑, *CREB↑, *BDNF↑, *OS↑, *cognitive↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Core Metabolism/Glycolysis ⓘ

CREB↑, 1, PPARα↑, 1,

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,

Functional Outcomes ⓘ

cognitive↑, 1, OS↑, 1,
Total Targets: 5

Scientific Paper Hit Count for: PPARα, Peroxisome Proliferator-Activated Receptor Alpha

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells