Apoptosis Cancer Research Results

Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
NPC, Nasopharyngeal Carcinoma (NPC): Click to Expand ⟱
Nasopharyngeal carcinoma, or nasopharynx cancer, is the most common cancer originating in the nasopharynx, most commonly in the postero-lateral nasopharynx or pharyngeal recess, accounting for 50% of cases.
Nasopharyngeal carcinoma (NPC) is a type of cancer that originates in the epithelial cells lining the nasopharynx, which is the upper part of the throat located behind the nose and above the soft palate.
-(NPC) is a malignant tumor which is commonly found in East Asia and Africa.
Scientific Papers found: Click to Expand⟱
4820- ASTX,    Astaxanthin suppresses the malignant behaviors of nasopharyngeal carcinoma cells by blocking PI3K/AKT and NF-κB pathways via miR-29a-3p
- in-vitro, NPC, NA
TumCP↓, TumCI↓, Apoptosis↑, TumCCA↑, cycD1/CCND1↓, Bcl-2↓, P21↑, BAX↑, PI3K↓, Akt↓, NF-kB↓, miR-29b↑,
7214- GAs,    Ginkgolic Acid Suppresses Nasopharyngeal Carcinoma Growth by Inducing Apoptosis and Inhibiting AKT/NF-κB Signaling
- vitro+vivo, NPC, CNE2
tumCV↓, TumCI↓, Apoptosis↑, Bcl-2↓, BAX↑, PARP↑, Casp3↑, Casp9↑, TumCCA↑, CDK6↓, CycD3↓, ChemoSen↑,
6569- Ger,    Geraniol inhibits cell growth and promotes caspase-dependent apoptosis in nasopharyngeal cancer C666-1 cells via inhibiting PI3K/Akt/mTOR signaling pathway
- in-vitro, NPC, C666-1
tumCV↓, MMP↓, Apoptosis↑, TBARS↑, GSH↓, SOD↓, BAX↑, Casp3↑, Casp9↑, PI3K↓, Akt↓, mTOR↓, DNAdam↑, ROS↑,
2360- SK,    Shikonin inhibits growth, invasion and glycolysis of nasopharyngeal carcinoma cells through inactivating the phosphatidylinositol 3 kinase/AKT signal pathway
- in-vitro, NPC, HONE1 - in-vitro, NPC, SUNE-1
TumCP↓, Apoptosis↑, TumCMig↓, TumCI↓, GlucoseCon↓, lactateProd↓, ATP↓, PKM2↓, PI3K↓, Akt↓, MMP3↓, MMP9↓, TIMP1↑,
4856- Uro,    Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro
- in-vitro, NPC, CNE1 - in-vitro, NPC, CNE2
Apoptosis↑, MMP↓, ROS↑, E-cadherin↑, BAX↑, cl‑Casp3↑, PARP↑, MMP2↓, MMP9↓, N-cadherin↓, Vim↓, Snail↓, eff↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   ROS↑, 2,   SOD↓, 1,   TBARS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GlucoseCon↓, 1,   lactateProd↓, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Apoptosis↑, 5,   BAX↑, 4,   Bcl-2↓, 2,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp9↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   CycD3↓, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   mTOR↓, 1,   PI3K↓, 3,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   miR-29b↑, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 2,   N-cadherin↓, 1,   Snail↓, 1,   TIMP1↑, 1,   TumCI↓, 4,   TumCMig↓, 2,   TumCP↓, 3,   Vim↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↓, 1,  
Total Targets: 42

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Apoptosis, Apoptosis
1 Astaxanthin
1 Ginkgolic acids
1 Geraniol
1 Shikonin
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:67  Cells:%  prod#:%  Target#:14  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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