CB2 / CNR2 Cancer Research Results

CB2 / CNR2, Cannabinoid receptor type 2: Click to Expand ⟱
Source:
Type:

CB2 / CNR2 : Druggable immune-enriched cannabinoid receptor involved in microglia, inflammation, immune-cell signaling, pain, neuroprotection, and tumor-immune regulation.

-when a product binds selectively to the CB2 receptors(modulates up) and not the CB1 receptor, it non-psychoactive and therapeutically appealing.
-activation of the CB2 receptor can suppress pro-inflammatory cytokines production, helping to create an anti-tumor immune environment

Field Suggested Entry
Target CB2 / CNR2
Full Name Cannabinoid receptor type 2
Target Class G-protein-coupled receptor; Gi/o-coupled cannabinoid receptor
Primary Biology Immune modulation, microglial activation, inflammatory signaling, cytokine regulation, leukocyte behavior, pain/inflammation signaling
Cancer Relevance Medium and context-dependent: may suppress inflammation or tumorigenesis in some settings, but may also support immune suppression or tumor progression depending on tumor type and immune context
AD Relevance Medium-high: microglial CB2 activation is a promising neuroinflammation strategy, with encouraging preclinical evidence in AD models but limited clinical validation
Therapeutic Direction Usually selective CB2 agonism/modulation for neuroinflammation and inflammatory disease; cancer direction is tumor-context-dependent
Key Product Links β-caryophyllene, PEA, CBD/cannabinoid-system modulators, endocannabinoids, omega-3-derived lipid mediators


MM, Malignant Mesothelioma: Click to Expand ⟱
Mesothelioma is a type of cancer that develops from the thin layer of tissue that covers many of the internal organs. The area most commonly affected is the lining of the lungs and chest wall.
Scientific Papers found: Click to Expand⟱
6512- BCP,    Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells
- in-vitro, MM, NA
CB2 / CNR2↑, BAX↑, Bcl-2↓, Casp3↑, TumCP↓, Apoptosis↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Inflam↓, chemoPv↑, neuroP↑, *BioAv↝, CB2 / CNR2↑, tumCV↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

CB2 / CNR2↑, 2,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Wnt↓, 1,  

Migration ⓘ

TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,   neuroP↑, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

BioAv↝, 1,  
Total Targets: 1

Scientific Paper Hit Count for: CB2 / CNR2, Cannabinoid receptor type 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:70  Cells:%  prod#:%  Target#:1500  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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