MMP9 Cancer Research Results

MMP9, MMP9: Click to Expand ⟱
Source: HalifaxProj(suppress)
Type:
Matrix metalloproteinase-9 (MMP-9) is an enzyme that plays a significant role in the degradation of extracellular matrix components.
MMP-9 facilitates the breakdown of the extracellular matrix, which can enable cancer cells to invade surrounding tissues and spread to distant sites (metastasis).
Elevated levels of MMP-9 have been associated with poor prognosis in several cancers, including breast, lung, and colorectal cancers.
MMP2 and MMP9: two enzymes are critical to tumor invasion.
CardioV, Cardiovascular Diseases: Click to Expand ⟱
Types of Cardiovascular Diseases
Coronary Artery Disease (CAD):
This is the most common type of CVD and occurs when the coronary arteries (which supply the heart with blood) are narrowed or blocked, typically due to atherosclerosis (the buildup of plaque). CAD can lead to chest pain (angina) or heart attacks.

Cerebrovascular Disease:
Diseases such as stroke fall under this category. A stroke occurs when blood flow to an area of the brain is interrupted, either by a clot (ischemic stroke) or by bleeding (hemorrhagic stroke).

Peripheral Artery Disease (PAD):
PAD involves the narrowing of peripheral arteries, often in the legs, which can cause pain and mobility issues.

Heart Failure:
Heart failure happens when the heart is unable to pump blood efficiently, leading to symptoms like shortness of breath, fatigue, and fluid retention.

Cardiac Arrhythmias:
These are problems related to the electrical system of the heart, which can cause irregular heartbeats. They range in severity from benign extra beats to life-threatening ventricular fibrillation.

Valvular Heart Diseases:
These diseases affect the heart valves, potentially causing conditions like stenosis (narrowing) or regurgitation (leakage), which can compromise the heart’s efficiency.
Scientific Papers found: Click to Expand⟱
4784- Lyco,    Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives
- Review, Diabetic, NA - Review, CardioV, NA
*antiOx↑, *IL8↓, *IL6↓, *IL1↓, *NF-kB↓, Inflam↓, cycD1/CCND1↓, MMP2↓, MMP9↓, Bcl-2↓, NF-kB↓, *Nrf1↑, *antiOx↑, *BDNF↑, *neuroP↑, *cardioP↑, ROS↑, Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Bcl-2↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Migration ⓘ

MMP2↓, 1,   MMP9↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Nrf1↑, 1,  

Immune & Inflammatory Signaling ⓘ

IL1↓, 1,   IL6↓, 1,   IL8↓, 1,   NF-kB↓, 1,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   neuroP↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: MMP9, MMP9
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:73  Cells:%  prod#:%  Target#:203  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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