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| Also called CCND1 Gatekeeper of Cell-Cycle Commitment The main function of cyclin D1 is to maintain cell cycle and to promote cell proliferation. Cyclin D1 is a key regulatory protein involved in the cell cycle, particularly in the transition from the G1 phase to the S phase. It is part of the cyclin-dependent kinase (CDK) complex, where it binds to CDK4 or CDK6 to promote cell cycle progression. Cyclin D1 is crucial for the regulation of the cell cycle. Overexpression or dysregulation of cyclin D1 can lead to uncontrolled cell proliferation, a hallmark of cancer. Cyclin D1 is often found to be overexpressed in various cancers. Cyclin D1 can interact with tumor suppressor proteins, such as retinoblastoma (Rb). When cyclin D1 is overexpressed, it can lead to the phosphorylation and inactivation of Rb, releasing E2F transcription factors that promote the expression of genes required for DNA synthesis and cell cycle progression. Cyclin D1 is influenced by various signaling pathways, including the PI3K/Akt and MAPK pathways, which are often activated in cancer. In some cancers, high levels of cyclin D1 expression have been associated with poor prognosis, making it a potential biomarker for cancer progression and treatment response. |
| Types of Cardiovascular Diseases Coronary Artery Disease (CAD): This is the most common type of CVD and occurs when the coronary arteries (which supply the heart with blood) are narrowed or blocked, typically due to atherosclerosis (the buildup of plaque). CAD can lead to chest pain (angina) or heart attacks. Cerebrovascular Disease: Diseases such as stroke fall under this category. A stroke occurs when blood flow to an area of the brain is interrupted, either by a clot (ischemic stroke) or by bleeding (hemorrhagic stroke). Peripheral Artery Disease (PAD): PAD involves the narrowing of peripheral arteries, often in the legs, which can cause pain and mobility issues. Heart Failure: Heart failure happens when the heart is unable to pump blood efficiently, leading to symptoms like shortness of breath, fatigue, and fluid retention. Cardiac Arrhythmias: These are problems related to the electrical system of the heart, which can cause irregular heartbeats. They range in severity from benign extra beats to life-threatening ventricular fibrillation. Valvular Heart Diseases: These diseases affect the heart valves, potentially causing conditions like stenosis (narrowing) or regurgitation (leakage), which can compromise the heart’s efficiency. |
| 4784- | Lyco, | Protective effects of lycopene in cancer, cardiovascular, and neurodegenerative diseases: An update on epidemiological and mechanistic perspectives |
| - | Review, | Diabetic, | NA | - | Review, | CardioV, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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