ARE Cancer Research Results

ARE, antioxidant responsive element (ARE): Click to Expand ⟱
Source:
Type:
antioxidant responsive element (ARE)
ARE in Normal Cells: Protective Role
ARE-regulated genes include NQO1, HO-1, GCLM, GCLC, and various glutathione S-transferases (GSTs).
-Detoxify reactive oxygen species (ROS)
-Agents like sulforaphane (from broccoli) can activate ARE in healthy cells to prevent cancer initiation.
-overactivation in cancer cells aids cancer survival, growth, resistance
CardioV, Cardiovascular Diseases: Click to Expand ⟱
Types of Cardiovascular Diseases
Coronary Artery Disease (CAD):
This is the most common type of CVD and occurs when the coronary arteries (which supply the heart with blood) are narrowed or blocked, typically due to atherosclerosis (the buildup of plaque). CAD can lead to chest pain (angina) or heart attacks.

Cerebrovascular Disease:
Diseases such as stroke fall under this category. A stroke occurs when blood flow to an area of the brain is interrupted, either by a clot (ischemic stroke) or by bleeding (hemorrhagic stroke).

Peripheral Artery Disease (PAD):
PAD involves the narrowing of peripheral arteries, often in the legs, which can cause pain and mobility issues.

Heart Failure:
Heart failure happens when the heart is unable to pump blood efficiently, leading to symptoms like shortness of breath, fatigue, and fluid retention.

Cardiac Arrhythmias:
These are problems related to the electrical system of the heart, which can cause irregular heartbeats. They range in severity from benign extra beats to life-threatening ventricular fibrillation.

Valvular Heart Diseases:
These diseases affect the heart valves, potentially causing conditions like stenosis (narrowing) or regurgitation (leakage), which can compromise the heart’s efficiency.
Scientific Papers found: Click to Expand⟱
4801- Lyco,    Lycopene in the Prevention of Cardiovascular Diseases
- Review, CardioV, NA
*BioAv↝, *cardioP↑, *BioAv↑, *BioAv↑, *antiOx↑, *ROS↓, *ARE↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *COX2↓, *Inflam↓, *IL1β↓, *IL6↓, *IL8↑, *TNF-α↓, *NF-kB↓, *BP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ARE↑, 1,   Catalase↑, 1,   GPx↑, 1,   lipid-P↓, 1,   ROS↓, 1,   SOD↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↑, 1,   Inflam↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 2,   BioAv↝, 1,  

Clinical Biomarkers ⓘ

BP↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,  
Total Targets: 19

Scientific Paper Hit Count for: ARE, antioxidant responsive element (ARE)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:73  Cells:%  prod#:%  Target#:1354  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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