BAX Cancer Research Results
BAX, Apoptosis regulator BAX: Click to Expand ⟱
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| Type: Proapototic protein |
BAX is a member of the Bcl-2 gene family.
Pro-apoptotic protein that forms heterodimers with anti-apoptotic BCL2 proteins; involved in various cellular activities and regulated by p53; mediates the release of cytochrome c from mitochondria.
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Park, Parkinson's Disease (PD): Click to Expand ⟱
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, and is due to the degeneration of dopaminergic neurons. It is multifactorial, caused by genetic and environmental factors and currently has no definitive cure.
-CoQ10 deficiency was observed at a higher frequency in Parkinson's disease
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Scientific Papers found: Click to Expand⟱
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Review, |
Var, |
NA |
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Review, |
Park, |
NA |
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Review, |
AD, |
NA |
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AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL6↑, *MMP13↓,
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in-vitro, |
Park, |
SH-SY5Y |
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*Apoptosis↓, *ROS↓, *BAX↓, *NF-kB↓, *P53↓, *p‑NF-kB↓,
Showing Research Papers: 1 to 2 of 2
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2
Pathway results for Effect on Cancer / Diseased Cells:
Mitochondria & Bioenergetics ⓘ
XIAP↓, 1,
Cell Death ⓘ
Akt↓, 1, Apoptosis↑, 1, Bak↓, 1, BAX↑, 1, Bcl-2↓, 1, BID↑, 1, Casp3↑, 1, Casp8↑, 1, Casp9↑, 1, Cyt‑c↑, 1, Fas↑, 1,
Kinase & Signal Transduction ⓘ
HER2/EBBR2↓, 1,
DNA Damage & Repair ⓘ
P53↑, 1, PARP↑, 1,
Cell Cycle & Senescence ⓘ
TumCCA↑, 1,
Proliferation, Differentiation & Cell State ⓘ
FGF↓, 1,
Migration ⓘ
CEA↓, 1, TIMP2↑, 1,
Angiogenesis & Vasculature ⓘ
EGFR↑, 1,
Immune & Inflammatory Signaling ⓘ
COX2↓, 1, NF-kB↑, 1,
Drug Metabolism & Resistance ⓘ
RadioS↑, 1,
Clinical Biomarkers ⓘ
CEA↓, 1, EGFR↑, 1, HER2/EBBR2↓, 1,
Functional Outcomes ⓘ
AntiCan↑, 1,
Total Targets: 27
Pathway results for Effect on Normal Cells:
NA, unassigned ⓘ
AntiBio↑, 2,
Redox & Oxidative Stress ⓘ
antiOx↑, 1, Catalase↑, 2, GSH↑, 2, Keap1↑, 1, lipid-P↓, 1, MDA↓, 1, ROS↓, 2, SOD↑, 2, TBARS↓, 1, uricA↓, 1,
Mitochondria & Bioenergetics ⓘ
ATP↑, 1, MMP↑, 1,
Cell Death ⓘ
Apoptosis↓, 2, BAX↓, 2, Bcl-2↑, 1, Casp3↓, 1, Cyt‑c↓, 1, iNOS↓, 2,
DNA Damage & Repair ⓘ
P53↓, 1,
Migration ⓘ
MMP13↓, 1,
Barriers & Transport ⓘ
BBB↑, 1, GastroP↑, 1,
Immune & Inflammatory Signaling ⓘ
CD4+↑, 1, COX2↓, 2, IL1β↓, 1, IL6↓, 1, IL6↑, 1, Imm↑, 1, Inflam↓, 1, NF-kB↓, 1, p‑NF-kB↓, 1, TNF-α↓, 2,
Synaptic & Neurotransmission ⓘ
AChE↓, 1, BChE↓, 1,
Protein Aggregation ⓘ
Aβ↓, 1, BACE↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↑, 2, eff↑, 1,
Clinical Biomarkers ⓘ
creat↓, 1, IL6↓, 1, IL6↑, 1,
Functional Outcomes ⓘ
cardioP↑, 2, motorD↑, 1, neuroP↑, 1, Pain↓, 1, RenoP↑, 1, toxicity↓, 1,
Infection & Microbiome ⓘ
AntiFungal↑, 1, CD8+↑, 1,
Total Targets: 50
Scientific Paper Hit Count for: BAX, Apoptosis regulator BAX
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:75 Cells:% prod#:% Target#:26 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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