BBB Cancer Research Results
BBB, Blood-Brain Barrier Permeability: Click to Expand ⟱
| Source: |
| Type: |
Blood-Brain Barrier(BBB) is a term often used regarding if a product has the ability to cross the BBB.
|
Park, Parkinson's Disease (PD): Click to Expand ⟱
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, and is due to the degeneration of dopaminergic neurons. It is multifactorial, caused by genetic and environmental factors and currently has no definitive cure.
-CoQ10 deficiency was observed at a higher frequency in Parkinson's disease
|
Scientific Papers found: Click to Expand⟱
| - |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Var, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
- |
Review, |
Stroke, |
NA |
|
|
|
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
*antiOx↑, *IronCh↑, *neuroP↑, *ROS↓, *Iron↓, *BBB↑, *motorD↑, *GSH↑,
| - |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
*neuroP↑, *antiOx↑, *ROS↓, *Inflam↓, *TNF-α↓, *IL1β↓, *PI3K↑, *Akt↑, *BBB↑, *NRF2↑, *SOD↑, *GPx↑, *MAPK↓, *Catalase↑, *HO-1↑, *COX2↓, *PGE2↓, *PPARγ↑, *TLR4↓, *GSK‐3β↓, *Aβ↓, *NLRP3↓, *BDNF↑, *TrkB↑, *GABA↑, *AChE↓, *Ach↑, *5HT↑, *cognitive↑, *MAOA↓,
| - |
Review, |
Var, |
NA |
|
|
|
- |
Review, |
Stroke, |
NA |
|
|
|
- |
Review, |
IBD, |
NA |
|
|
|
- |
Review, |
Arthritis, |
NA |
|
|
|
- |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
cardioP↑, Inflam↓, cognitive↑, *hepatoP↑, *ROS?, *SOD↑, *GSH↑, *MMP↑, *GutMicro↑, ChemoSen↑, *TNF-α↓, *IL10↑, *IL6↓, *eff↑, *ROS↓, *COX2↓, *NF-kB↓, *STAT3↓, *PGE2↓, *MPO↓, *IL1β↓, *MMP2↓, *MMP9↓, *β-Amyloid↓, *neuroP↑, *Dose↝, *BioAv↝, *BioAv↝, *BBB↑, *BDNF↑,
| - |
Review, |
Stroke, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
- |
Review, |
AD, |
NA |
|
|
|
*neuroP↑, *antiOx↑, *Inflam↓, *BioAv↝, *BioAv↑, *Half-Life↝, *TLR4↓, *NF-kB↓, *iNOS↓, *COX2↓, *TNF-α↓, *12LOX↓, *NLRP3↓, *ROS↓, *IL1β↓, *IL6↓, *GSK‐3β↓, *NRF2↑, *BBB↑, *SOD↑, *GPx↑, *MDA↓,
| - |
Review, |
GBM, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
- |
Review, |
AD, |
NA |
|
|
|
BBB↑, *GSH↑, *Catalase↑, *motorD↑, *neuroP↑, *cognitive↑, *ROS↓, *antiOx↑, *Inflam↓, MMP↓, STAT3↓, NF-kB↓, Sp1/3/4↓, TOP1↓, EMT↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, BioAv↓,
| - |
Review, |
Var, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
- |
Review, |
AD, |
NA |
|
|
|
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2↓, *TNF-α↓, *IL6↑, *MMP13↓,
| - |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
*memory↑, *cognitive↑, *ROS↓, *Inflam↓, *motorD↑, *toxicity↓, *TRPV3↑, *other↓, *antiOx↑, *LDL↓, *COX2↓, *PPARα↑, *NO↓, *AChE↓, *eff↑, *SOD↑, *Catalase↑, *neuroP↑, *BioAv↝, *BBB↑, *BioAv↑,
| - |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
- |
Review, |
Stroke, |
NA |
|
|
|
*Inflam↓, *antiOx↑, *AChE↓, *BBB↑, *cardioP↑, *neuroP↑, *memory↑, *TAC↑, *ROS↓, *lipid-P↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *cognitive↑, *IL1β↓, *COX2↓, *TNF-α↓, *TLR4↓, *BDNF↑, *PKCδ↑, *5LO↓, *TRPM7↓, *GSH↑, *other↑, *Ferroptosis↓, *GPx4↑,
| - |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
*ROS↓, *neuroP↑, *BDNF↑, *NRF2↑, *BBB↑, *HSPs↑, *GSH↑, *TG2/TGase↓, Aβ↓,
| - |
Review, |
Nor, |
NA |
|
|
|
- |
Review, |
Stroke, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
*antiOx↑, *ROS↓, *neuroP↑, *NO↑, BioAv↝, *BBB↑, *toxicity↑, *eff↑, *GSH↑, *SOD↑, *Aβ↓, *12LOX↓, *COX2↓, *Catalase↑, *Inflam↓, *TNF-α↓, *IL6↑, *lipid-P↓, NF-kB↓, IL1β↓, NRF2↑, HO-1↑, GSTs↑, cognitive↑, *BDNF↑,
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
| - |
in-vivo, |
ALS, |
NA |
|
|
|
- |
NA, |
Stroke, |
NA |
|
|
|
- |
NA, |
AD, |
NA |
|
|
|
- |
NA, |
Park, |
NA |
|
|
|
*eff↑, *ROS↓, *GSH↑, *NRF2↑, *motorD↑, *OS↑, *neuroP↑, *BBB↑, *cognitive↑, *eff↑, *antiOx↑, *Cyt‑c↑, *PGC-1α↑,
| - |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
- |
Review, |
MS, |
NA |
|
|
|
- |
Review, |
Stroke, |
NA |
|
|
|
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↝, *BBB↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL8↓, *IL33↓, *NF-kB↓, *BACE↓, *ROS↓, *SOD↑, *HO-1↑, *NRF2↑, *Casp3↓, *Casp9↑, *Bax:Bcl2↓, *UPR↑, *GRP78/BiP↑, *Aβ↓, *GSK‐3β↓, *tau↓, *CREB↑, *ATP↑, *cognitive↑, *BloodF↑, *BDNF↑, *TrkB↑, *memory↑, *PPARγ↑, *eff↑,
| - |
Review, |
Var, |
NA |
|
|
|
- |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑,
| - |
Review, |
Nor, |
NA |
|
|
|
- |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
| - |
Review, |
Stroke, |
NA |
|
|
|
- |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
*eff↑, *BBB↑, *Dose↝, *neuroP↑, *cognitive↑, *toxicity∅,
| - |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
*BBB↑, *BDNF↑, *neuroG↑, *NRF2↑, *HO-1↑, *Catalase↑, *SOD↑, *HSPs↑, *GSTs↑, *Trx↑, *GPx↑, *GSR↑, *GSH↑, *NQO1↑, *GutMicro↑, *Inflam↓, *neuroP↑,
| - |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
*antiOx↑, *Inflam↓, *Half-Life↝, *NRF2↑, *NQO1↑, *HO-1↑, *TrxR↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *Aβ↓, *GSH↑, *cognitive↑, *BACE↓, *HSP70/HSPA5↑, *neuroP↑, *ROS↓, *BBB↑, *MMP9↓,
| - |
Review, |
Var, |
NA |
|
|
|
- |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
*Dose↝, *BioEnh↑, *BBB↑, *ROS↓, *GSH↑, *SOD↑, *GSR↑, *NO↓, *P450↓, OS↑, TumCG↓, *GutMicro↑, *Pain↓, *neuroP↑, *AChE↓, *BDNF↑, *Bacteria↓, *AntiFungal↑, *toxicity↓,
| - |
Review, |
AD, |
NA |
|
|
|
- |
Review, |
Park, |
NA |
|
|
|
- |
Review, |
Stroke, |
NA |
|
|
|
*MitoP↑, *Inflam↓, *antiOx↑, *Risk↓, *Aβ↓, *p‑tau↓, *p62↓, *PARK2↑, *MMP↑, *ROS↓, *Strength↑, *CRP↓, *IL1β↓, *IL6↓, *TNF-α↓, *AMPK↑, *NF-kB↓, *MAPK↓, *p62↑, *NRF2↑, *SOD↑, *Catalase↑, *HO-1↑, *Ferroptosis↓, *lipid-P↓, *Cartilage↑, *PI3K↓, *Akt↓, *mTOR↓, *Apoptosis↓, *neuroP↑, *Bcl-2↓, *BAX↑, *Casp3↑, *ATP↑, *eff↑, *motorD↑, *NLRP3↓, *radioP↑, *BBB↑,
Showing Research Papers: 1 to 21 of 21
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 21
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress(tgid=1) ⓘ
Catalase↓, 1, GSH↓, 1, GSTs↑, 1, HO-1↑, 1, NRF2↓, 1, NRF2↑, 1, ROS↓, 1, ROS↑, 2, SOD↓, 1, Trx1↑, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
CDC2↓, 1, MMP↓, 2, XIAP↓, 1,
Cell Death(tgid=5) ⓘ
Akt↓, 2, p‑Akt↓, 1, APAF1↑, 1, Apoptosis↑, 2, Bak↓, 1, BAX↑, 2, Bcl-2↓, 3, BID↑, 1, Casp12↑, 1, Casp3↑, 3, Casp8↑, 2, Casp9↑, 3, proCasp9↓, 1, Cyt‑c↑, 3, DR5↑, 1, Fas↑, 2, hTERT/TERT↓, 1, MAPK↑, 1, MDM2↓, 1, p38↑, 1,
Kinase & Signal Transduction(tgid=6) ⓘ
HER2/EBBR2↓, 1, Sp1/3/4↓, 1,
Autophagy & Lysosomes(tgid=9) ⓘ
Beclin-1↑, 1, BNIP3↑, 1,
DNA Damage & Repair(tgid=10) ⓘ
CHK1↓, 1, P53↑, 3, PARP↑, 1,
Cell Cycle & Senescence(tgid=11) ⓘ
CDK2↓, 2, cycA1/CCNA1↑, 1, CycB/CCNB1↓, 2, P21↑, 1, TumCCA↑, 3,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
EMT↓, 2, p‑ERK↓, 1, FGF↓, 1, NOTCH↓, 1, PI3K↓, 1, STAT3↓, 2, p‑STAT3↓, 1, TOP1↓, 1, TumCG↓, 1,
Migration(tgid=13) ⓘ
CEA↓, 1, E-cadherin↑, 1, FAK↓, 1, p‑FAK↓, 1, MMP2↓, 1, MMP9↓, 1, N-cadherin↓, 1, Snail↓, 1, TIMP2↑, 1, TumCMig↓, 1, Twist↓, 1, Vim↓, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
EGFR↑, 1, p‑EGFR↓, 1, Hif1a↓, 2, VEGF↓, 3, VEGFR2/KDR/Flk1↓, 1,
Barriers & Transport(tgid=15) ⓘ
BBB↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
COX2↓, 1, IL1↓, 1, IL1β↓, 1, IL6↓, 1, IL8↓, 1, Inflam↓, 1, NF-kB↓, 3, NF-kB↑, 1, TNF-α↓, 1,
Protein Aggregation(tgid=19) ⓘ
Aβ↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
BioAv↓, 1, BioAv↝, 1, ChemoSen↑, 3, RadioS↑, 2,
Clinical Biomarkers(tgid=22) ⓘ
CEA↓, 1, EGFR↑, 1, p‑EGFR↓, 1, GutMicro↑, 1, HER2/EBBR2↓, 1, hTERT/TERT↓, 1, IL6↓, 1,
Functional Outcomes(tgid=23) ⓘ
AntiCan↑, 2, cardioP↑, 2, chemoP↑, 1, cognitive↑, 2, OS↑, 1,
Total Targets: 98
Pathway results for Effect on Normal Cells:
NA, unassigned(tgid=0) ⓘ
AntiBio↑, 2,
Redox & Oxidative Stress(tgid=1) ⓘ
antiOx↑, 17, Catalase↑, 10, Ferroptosis↓, 2, GPx↑, 4, GPx4↑, 1, GSH↑, 14, GSR↑, 4, GSTs↓, 1, GSTs↑, 3, H2O2↓, 1, HO-1↑, 7, Iron↓, 1, Keap1↓, 1, Keap1↑, 1, lipid-P↓, 6, MDA↓, 4, MPO↓, 3, NQO1↑, 2, NRF2↑, 13, PARK2↑, 1, ROS?, 1, ROS↓, 21, SOD↑, 15, TAC↑, 2, TBARS↓, 2, Trx↑, 1, TrxR↑, 1, uricA↓, 1, VitC↑, 1, VitE↑, 1,
Metal & Cofactor Biology(tgid=2) ⓘ
IronCh↑, 1,
Mitochondria & Bioenergetics(tgid=3) ⓘ
ATP↑, 3, MMP↑, 4, PGC-1α↑, 1,
Core Metabolism/Glycolysis(tgid=4) ⓘ
12LOX↓, 2, ALAT↓, 1, AMPK↑, 2, CREB↑, 1, H2S↑, 1, LDH↓, 2, LDL↓, 1, NADPH↓, 1, PPARα↑, 1, PPARγ↑, 2, SIRT1↑, 1,
Cell Death(tgid=5) ⓘ
Akt↓, 3, Akt↑, 1, Apoptosis↓, 2, BAX↓, 1, BAX↑, 1, Bax:Bcl2↓, 1, Bcl-2↓, 1, Bcl-2↑, 1, Casp3↓, 2, Casp3↑, 1, Casp9↑, 1, Cyt‑c↓, 1, Cyt‑c↑, 1, Ferroptosis↓, 2, iNOS↓, 5, MAPK↓, 3,
Kinase & Signal Transduction(tgid=6) ⓘ
TRPV3↑, 1,
Transcription & Epigenetics(tgid=7) ⓘ
Ach↑, 1, other↓, 1, other↑, 2,
Protein Folding & ER Stress(tgid=8) ⓘ
GRP78/BiP↑, 1, HSP70/HSPA5↑, 1, HSPs↑, 2, UPR↑, 1,
Autophagy & Lysosomes(tgid=9) ⓘ
MitoP↑, 1, p62↓, 1, p62↑, 1,
Proliferation, Differentiation & Cell State(tgid=12) ⓘ
GSK‐3β↓, 3, mTOR↓, 1, p‑mTOR↓, 1, neuroG↑, 1, PI3K↓, 2, PI3K↑, 1, STAT3↓, 1, TRPM7↓, 1,
Migration(tgid=13) ⓘ
5LO↓, 1, Cartilage↑, 1, MMP13↓, 1, MMP2↓, 1, MMP9↓, 2, PKCδ↑, 1, TG2/TGase↓, 1, TGF-β1↑, 1,
Angiogenesis & Vasculature(tgid=14) ⓘ
NO↓, 5, NO↑, 1,
Barriers & Transport(tgid=15) ⓘ
BBB↑, 20, GastroP↑, 1,
Immune & Inflammatory Signaling(tgid=16) ⓘ
CD4+↑, 1, COX2↓, 11, CRP↓, 1, IL10↑, 2, IL1β↓, 10, IL33↓, 1, IL6↓, 9, IL6↑, 2, IL8↓, 1, Imm↑, 1, Inflam↓, 14, NF-kB↓, 7, PGE2↓, 3, TLR4↓, 3, TNF-α↓, 13,
Synaptic & Neurotransmission(tgid=18) ⓘ
5HT↑, 1, AChE↓, 6, BChE↓, 1, BDNF↑, 8, GABA↑, 1, MAOA↓, 1, tau↓, 1, p‑tau↓, 1, TrkB↑, 2,
Protein Aggregation(tgid=19) ⓘ
Aβ↓, 7, BACE↓, 3, NLRP3↓, 4, β-Amyloid↓, 1,
Drug Metabolism & Resistance(tgid=21) ⓘ
BioAv↓, 2, BioAv↑, 5, BioAv↝, 6, BioEnh↑, 1, Dose↝, 3, eff↑, 10, Half-Life↑, 1, Half-Life↝, 3, P450↓, 1,
Clinical Biomarkers(tgid=22) ⓘ
ALAT↓, 1, AST↓, 1, BloodF↑, 1, BP↓, 1, creat↓, 2, CRP↓, 1, GutMicro↑, 4, IL6↓, 9, IL6↑, 2, LDH↓, 2,
Functional Outcomes(tgid=23) ⓘ
cardioP↑, 5, cognitive↑, 9, hepatoP↑, 2, memory↑, 5, motorD↑, 6, neuroP↑, 23, OS↑, 1, Pain↓, 2, radioP↑, 1, RenoP↑, 1, Risk↓, 1, Strength↑, 1, toxicity↓, 3, toxicity↑, 1, toxicity∅, 1,
Infection & Microbiome(tgid=24) ⓘ
AntiFungal↑, 2, Bacteria↓, 1, CD8+↑, 1, Sepsis↓, 1,
Total Targets: 159
Scientific Paper Hit Count for: BBB, Blood-Brain Barrier Permeability
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:75 Cells:% prod#:% Target#:1123 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
Home Page