DNAdam Cancer Research Results

DNAdam, DNA damage: Click to Expand ⟱
Source: HalifaxProj(prevent)
Type:
DNA damage plays a crucial role in the development of cancer. The integrity of DNA is essential for the proper functioning of cells, and when DNA is damaged, it can lead to mutations that may contribute to cancer progression.
Mye, Myeloma: Click to Expand ⟱

Myeloma - Plasma Cell Malignancy

Alternative Names: Multiple myeloma, plasma cell myeloma

Type: Hematologic malignancy / plasma cell cancer

Origin: Malignant transformation and clonal expansion of antibody-producing plasma cells, usually within the bone marrow.

Function/Characteristics: Myeloma cells produce monoclonal immunoglobulins or light chains and can disrupt normal bone marrow function, bone remodeling, renal function, and immune regulation.

Common Features: Bone marrow infiltration, osteolytic bone lesions, anemia, elevated monoclonal protein, renal dysfunction, hypercalcemia, and impaired normal antibody production.

Common Markers: CD38, CD138, BCMA (TNFRSF17), SLAMF7, and monoclonal immunoglobulin/light-chain expression.
Scientific Papers found: Click to Expand⟱
7437- CYN,    Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myeloma
- in-vitro, Mye, AMO1 - in-vivo, Mye, NA - in-vitro, Mye, KMS11 - in-vitro, Mye, JJN3 - in-vitro, Mye, MolP8 - in-vitro, Mye, L363 - in-vitro, Mye, H929
tumCV↓, cMyc↓, STAT3↓, Akt↓, ERK↓, TumCCA↑, DNAdam↑, PARP1↑, AIF↑, TumCG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   PARP1↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   STAT3↓, 1,   TumCG↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: DNAdam, DNA damage
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:92  Cells:%  prod#:%  Target#:82  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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