talin Cancer Research Results

talin, talin: Click to Expand ⟱
Source:
Type:
Talin is a cytoskeletal protein that plays a central role in linking integrins to the actin cytoskeleton. Two major isoforms exist—talin-1 and talin-2.

-Talin serves as a key mediator of integrin activation and cytoskeletal organization, functions that underpin its role in regulating cell adhesion, migration, and invasion.
-In several cancers—including breast, prostate, and colorectal cancers—elevated expression of talin (most notably talin-1) has been associated with more aggressive tumor behavior, increased metastatic potential, and poorer clinical outcomes.
Scientific Papers found: Click to Expand⟱
175- Api,    Apigenin up-regulates transgelin and inhibits invasion and migration of colorectal cancer through decreased phosphorylation of AKT
- vitro+vivo, CRC, SW480 - vitro+vivo, CRC, DLD1 - vitro+vivo, CRC, LS174T
MMP↓, p‑Akt↓, TumCP↓, TumCI↓, NADH↓, HSP90↓, other↑, talin?,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

NADH↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Protein Folding & ER Stress ⓘ

HSP90↓, 1,  

Migration ⓘ

talin?, 1,   TumCI↓, 1,   TumCP↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: talin, talin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1288  State#:%  Dir#:0
  wNotes=0  sortOrder:rid,rpid

 

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