GSDMD Cancer Research Results

GSDMD, gasdermin D: Click to Expand ⟱

Source:

Type:

GSDMD is best known for its central role in mediating pyroptosis, a form of inflammatory programmed cell death.

-Some studies suggest that increased GSDMD expression and associated pyroptosis may improve local antitumor immunity.
-Some preclinical studies indicate that enhanced pyroptosis via GSDMD activation may correlate with a better prognosis, likely through improved immune-mediated clearance of tumor cells.

Scientific Papers found: Click to Expand⟱

3472-

MF,

GSDMD_signaling_path">Pulsed electromagnetic field alleviates synovitis and inhibits the NLRP3/Caspase-1/GSDMD signaling pathway in osteoarthritis rats

in-vivo,

ostP,

3.82 mT, 8 Hz, 40 min/day, 5 days a week, for 12 weeks.

three-month-old Sprague-Dawley (SD)

*Inflam↓, Pulsed electromagnetic field (PEMF) can improve the symptoms of OA and potentially acts as an anti-inflammatory
*NLRP3↓, the over-expression of NLRP3, Caspase-1, and GSDMD in the cartilage of the OA rats decreased after PEMF treatment.
*Casp1↓,
*GSDMD?,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Cell Death ⓘ

Casp1↓, 1, GSDMD?, 1,

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,

Protein Aggregation ⓘ

NLRP3↓, 1,
Total Targets: 4

Scientific Paper Hit Count for: GSDMD, gasdermin D

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells