ADAM10 Cancer Research Results

ADAM10, A Disintegrin And Metalloproteinase Domain-Containing Protein 10: Click to Expand ⟱
Source:
Type:
ADAM10 (A Disintegrin And Metalloproteinase Domain-Containing Protein 10) plays a critical protective role in Alzheimer’s disease (AD) due to its function as an α-secretase, an enzyme involved in the non-amyloidogenic processing of the amyloid precursor protein (APP).
-By preventing Aβ accumulation, ADAM10 indirectly reduces amyloid plaques.br> -Downregulation of ADAM10 is observed in AD brains.
-ADAM10 levels are especially diminished in individuals with an APOE4 genotype
Scientific Papers found: Click to Expand⟱
5932- CAR,    Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
- in-vivo, IBD, NA - in-vivo, Park, NA
*GutMicro↑, Risk↓, *Inflam↓, *antiOx↓, *ZO-1↑, *iNOS↓, *IL6↓, *NO↓, *PGE2↓, *memory↑, *TLR4↓, *NF-kB↓, *IBI↑, *CLDN3↑, *CLDN1↑, *MUC1↑, *OCLN↑, *iNOS↑, *COX2↓, *IFN-γ↓, IL1β↓, ADAM10?,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,  

Synaptic & Neurotransmission ⓘ

ADAM10?, 1,  

Functional Outcomes ⓘ

Risk↓, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,  

Cell Death ⓘ

iNOS↓, 1,   iNOS↑, 1,  

Migration ⓘ

CLDN1↑, 1,   MUC1↑, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

CLDN3↑, 1,   IBI↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IFN-γ↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   TLR4↓, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

memory↑, 1,  
Total Targets: 20

Scientific Paper Hit Count for: ADAM10, A Disintegrin And Metalloproteinase Domain-Containing Protein 10
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1368  State#:%  Dir#:0
  wNotes=0  sortOrder:rid,rpid

 

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