other Cancer Research Results
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Scientific Papers found: Click to Expand⟱
*COX1↓, believed that acetaminophen induces analgesia by inhibiting cyclooxygenase enzymes
*other?, believed that acetaminophen is metabolized to p-aminophenol, which crosses the blood-brain barrier and gets metabolized by fatty acid amide hydrolase to yield N-acylphenolamine (AM404).
*BBB↑,
TRPV1↑, by activating TRPV1 receptor, AM404 produced outward currents that were measured using whole-cell patch-clamp recordings and acted as a partial agonist in trigeminal neurons
*other?, co-administration of AS-IV could decrease the systemic exposure of omeprazole significantly
*P-gp↑, it might exert these effects through decreasing the absorption of omeprazole by inducing P-gp, or through accelerating the metabolism of omeprazole in rat liver by inducing the activity of CYP3A4.
*CYP3A4↑,
*BBB↑, alpha linolenic acid (ALA), the precursor of the majoritarian brain component docosahexaenoic acid (DHA), emerges as a potential novel brain savior, acting via BBB functional improvements,
*other↑, Apolipoprotein E4 (ApoE4) allele carriers are at increased risk to develop AD compared with those carrying the ApoE3 or E2 alleles
*other↑, Our emerging, yet unpublished results, suggest that ALA dietary enrichment in ApoE4 compared with ApoE3 mice brain, restores part of the decreased lipids, and in particular cholesterol and phospholipids, and leads to DHA enrichment in brain blood ve
*DHA↑, We propose that, by conversion to DHA, ALA– the natural substrate in the DHA metabolic pathway– may produce the DHA beneficial effects on BBB and brain health.
*neuroP↑, It has also been shown that DHA confers long-term protection against ischemic brain damage through multiple mechanisms, including suppression of inflammatory responses, decrease in oxidative stress and stimulation of angiogenesis and neurogenesis
*ROS↓,
*other?, while AD pathology follows a long preclinical course, with DHA decrease being a hallmark of brain deterioration with aging [67].
*BChE↓, Essential oils (EOs) from Salvia leriifolia Benth. exhibited high BChE inhibitory.
*AChE↓, Volatile oil from Marlierea racemosa Vell. (Myrtaceae) demonstrated concentration‐dependent inhibition of AChE
*other↓, EOs from the leaves and flowers of Polygonum hydropiper L., 28 sandalwood oil and its chief constituent α‐santalol were reported the AChE, BChE inhibitory efficacy.
*other?, The extract of Rosmarinus officinalis L. leaf led to improved long‐term memory in scopolamine‐induced rats, which can be partially explained by its inhibition of AChE activity in rat brain
*Ach?, It was observed in APP/PS1 mice that 4 weeks of Lemon essential oil treatment could significantly decrease hippocampal AChE, and thus increased ACh levels
*eff↑, Most studies have found that terpenoids in aromatic plant extracts are the main anticholinesterase active components
*antiOx↑, aromatic plant extracts for their potent antioxident and free radical scavenging properties
*ROS↓, Several compounds like safranal, linalool, and SHXW essential oil have been found to decrease ROS levels induced by Aβ in rats or mouse
*cognitive↑, aromatic plant extracts can improve cognitive function, reduce agitation, and improve sleep quality in AD patients.
*Mood↑,
*Sleep↑,
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in-vitro, |
CRC, |
HCT116 |
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in-vitro, |
Nor, |
NCM460 |
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in-vitro, |
CRC, |
HT29 |
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in-vitro, |
CRC, |
HCT8 |
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Ferroptosis↑, Artemisia annua, acted as a CRC therapeutic agent by promoting calcium-dependent ferroptosis.
CYP24A1↓, ATT repressed cytochrome P450 family 24 subfamily A member 1 (CYP24A1) expression, the pivotal mediator of this response
Ca+2↑, ATT downregulated CYP24A1 expression to elevate calcium levels and induce ferroptosis in CRC cells
SCD1↓, The ensuing calcium overload downregulated stearoyl-CoA desaturase (SCD) by CAMKK2/AMPK/SREBF1 axis, enriching oxidizable fatty acids and sensitizing CRC cells to lethal lipid peroxidation.
FAO↑,
lipid-P↑,
eff↑, The results showed that ATT exhibited the highest cytotoxicity, surpassing that of dihydroartemisinin and artesunate, whereas artemisinin and artemether were only weakly effective
selectivity↑, ATT induced cell death in a strictly time-dependent manner and displayed minimal toxicity toward normal NCM460 epithelial cells
other?, Collectively, these data reveal that ATT-driven calcium overload disrupts fatty-acid homeostasis via SCD inhibition, thereby steering CRC cells toward ferroptosis.
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in-vitro, |
Melanoma, |
B16-F10 |
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other↓, Baicalein significantly inhibited melanin synthesis in a concentration-dependent manner without cytotoxicity
other?, Tyrosinase activity was also reduced.
ERK↑, Western blotting showed that baicalein induced ERK activation
*AntiAg↑, berberine selectively inhibits collagen-induced platelet aggregation
*other?, Since berberine was unable to inhibit the aggregation mediated by activation of thromboxane A2, increase in calcium influx, or stimulation of G-protein linked pathways, it is likely that berberine selectively inhibits platelet aggregation by interfer
*memory↓, Results demonstrated slower reaction time in an image discrimination task in the BM group and faster reaction time in a spatial working memory task (SWM-O RT) in the placebo group.
*other?, Given the exploratory outcomes and inconsistent findings between the behavioral and neuroimaging data, a larger study is needed to confirm the synaptogenic mechanisms of BM.
*antiOx↑, CoQ10 can potentially increase the production of vital antioxidants, such as superoxide dismutase, an enzyme that effectively mitigates vascular oxidative stress in individuals with hypertension. I
*SOD↑,
*lipid-P↓, CoQ10 lowers lipid peroxidation levels by diminishing pro-oxidative compounds.
*ROS↓,
*other?, CoQ10 can improve blood flow and safeguard blood vessels by preserving nitric oxide
homoC↓, Vitamin B12 and folic acid are required for the remethylation reaction of homocysteine
eff↑, Homocysteine has been reported to be increased in a number of cancers includinghead and neck cancers,breast cancers,prostate cancers and colon cancers.
eff↑, Vitamin B12 and folate levels are significantly decreased in cancer patients.
eff↑, homocysteine levels are positively associated with proliferation rates of cells in a variety of tumors including head and neck and breast cancers [2] as well as with oxidative damage to cells
eff↝, cysteine may act as prooxidant agent that causes DNA oxidative damage as a result of the over production of free radicals and hydrogen peroxide ,leading to gene mutation and subsequent cancer development
homoC↝, It was observed that mean homocysteine levels were significantly increased almost double in cancer patients when compared to control subjects
other?, In the high homocysteine group Vitamin B12 was found to be significantly decreased
eff↑, Ferumoxytol-enhanced MRA has many advantages including that it is safe for patients with renal failure and provides a lengthy plateau of vascular signal as a blood pool agent that allows longer navigated MRA sequences.
toxicity↓, safe for patients with renal failure
other?, safety in cancer not mentioned?
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Review, |
CRC, |
NA |
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- |
Review, |
Lung, |
NA |
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- |
Review, |
BC, |
NA |
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Inflam↑, Oxyhydrogen gas, a mixture of 66% molecular hydrogen (H2) and 33% molecular oxygen (O2) has shown exceptional promise as a novel therapeutic agent due to its ability to modulate oxidative stress, inflammation, and apoptosis.
ROS↓, neutralises reactive oxygen and nitrogen species
ChemoSen↑, enhancing existing treatments and reducing harmful oxidative states in cancer cells. boosting the effectiveness of conventional therapies
p‑PI3K↓, inhibiting the PI3K/Akt phosphorylation cascade.
p‑Akt↓,
QoL↑, Similar results have been observed in breast cancer, where patients reported improved quality of life.
GutMicro↑, improves intestinal microflora dysbiosis.
chemoP↑, reduced oxidative stress and mitigated tissue damage, suggesting its potential as a cytoprotective agent in cancer patients undergoing radiation therapy or chemotherapy
radioP↑,
*NRF2↑, documented role in activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
*Catalase↑, consequently, hydrogen can enhance the expression of endogenous antioxidant enzymes, including catalase (CAT), glutathione peroxidase (GPx), haem oxygenase (e.g., HO-1), and superoxide dismutase (SOD) [45]
*GPx↑,
*HO-1↑,
*SOD↑,
*TNF-α↓, reducing the expression of proinflammatory mediators such as chemokines (e.g., CXCL15), cytokines (e.g., TNF-α), interleukins (e.g., IL-4, IL-6)
*IL4↓,
*IL6↓,
ChemoSen↑, further research demonstrates that oxyhydrogen gas enhanced the sensitivity of lung cancer cells to chemotherapy drugs, suggesting its potential as an adjuvant therapy
Appetite↑, inhaled oxyhydrogen gas over a minimum of 3 months. The results indicated substantial improvements in appetite, cognition, fatigue, pain, and sleeplessness
cognitive↑,
Pain↓,
Sleep↑,
other?, It is recommended that hydrogen should not exceed 4.6% in air or 4.1% by volume in pure oxygen gas (explosion risk)
*Inflam↓, Pulsed electromagnetic field therapy (PEMF) (1‐50 Hz) is effective in reducing tissue inflammation.
*Dose↝, Magcell® Microcirc, Physiomed Elektromedizin AG, Scnaittach, Germany, Figure 2), with a frequency of 4‐12 Hz and an intensity of 1000 Gauss
*other?, The overall effect is a reduction in tissue hypoxia and therefore a reduction in prostatic growth
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in-vivo, |
Wounds, |
L929 |
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- |
NA, |
NA, |
HaCaT |
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*ROS↑,
*Ca+2↓,
*other↝, (i) WMF can evoke new tissue production/regeneration (stem cell proliferation and subsequent differentiation) due to manipulation of ROS levels and also downstream heat shock protein 70 (Hsp70) expression
*other↝, (ii) The magnetic field causes changes in membrane potential and temporary membrane permeabilization that affects sodium content and potassium-efflux or the transmembrane voltage
*other↝, (iii) The calcium gradient between the extracellular and intracellular fluid is a transduction second messenger [28], and its gradient could potentially be affected by EMFs and MFs.
*other↝, (iv) MF may induce changes in enzymatic activities (e.g., enzymes involved in mitochondrial metabolism).
*other↝, (v) MF may cause cytoskeletal organization (due to reorganization of the electrostatically negative charged actin filaments), and those changes may affect the cellular shape, endoplasmic reticulum, mitotic apparatus
*other?, vi) Finally, the RMF creates the mixing process at the micro-level and may affect the energy level; some of the selected molecules strongly influence the transfer processes between the living cells and the culture medium
HDAC↓, Phenylbutyrate is one of the first drugs encountered in cancer therapy as a histone deacetylase inhibitor (HDACI).
TumCCA↑, phenylbutyrate treatment that results in reduced proliferation and cell-cycle arrest in G1 or G2 phases.
P21↑, common sequela of phenylbutyrate treatment is the upregulation of p21,
Dose↝, In prostate cancer, phenylbutyrate at clinically achievable concentrations (0.1 mM-8 mM),
Telomerase↓, butyrate or its derivatives was also evident in several other types of cancers and was associated with loss of telomerase activity
IGFBP3↑, Upregulation of insulin-like growth factor binding protein 3 (IGFBP-3) is another unique antiproliferative mechanism of sodium butyrate in breast cancer cells
p‑p38↑, Phenylbutyrate and its derivatives upregulated p21, gelsolin, phosphorylated p38, JNK, and ERK (MAPK pathway members), Bax, caspases-3,
JNK↑,
ERK↑,
BAX↑,
Casp3↑,
Bcl-2↓, downregulated Bcl-X L , Bcl-2, cytochrome c, FAK, and survivin
Cyt‑c↝,
FAK↓,
survivin↓,
VEGF↓, Butyrate treatment reduced the level of vascular endothelial growth factor (VEGF)
angioG↓,
DNArepair↓, Inhibition of DNA Repair.
TumMeta↓,
HSP27↑, Moreover, butyrate treatment in colorectal cancer cells resulted in an acute stress response that was associated with HSP27 activation, activation of ASK1 (MAP3K) and p38 MAPK pathway consequently.
ASK1↑,
ROS↑, Also it resulted in elevated cellular levels of reactive oxygen species (ROS) in oral and tongue cancer cells.
eff↑, phenylbutyrate enhanced the cytotoxicity of temozolamide in malignant glioma cells via suppression of the endoplasmic reticulum stress revealed by the decreased expression of GRP78 and GADD153.
ER Stress↓,
GRP78/BiP↓,
CHOP↑, GADD153
AR↓, Sodium butyrate treatment of prostate cancer cells was associated with downregulation of androgen receptor
other?, lots of references in this paper.
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in-vitro, |
CRC, |
Caco-2 |
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in-vivo, |
Nor, |
HCEC 1CT |
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TumCG↓,
Glycolysis↓,
PPP↓,
ATP↑, significant increase (20%) in ATP production
PDH↑, Resveratrol targets the pyruvate dehydrogenase (PDH) complex, a key mitochondrial gatekeeper of energy metabolism, leading to an enhanced PDH activity.
Ca+2↝, resveratrol is a potent modulator of many cellular Ca2+ signaling pathways.
Ca2+ is a key mediator of the effect of resveratrol on the oxidative capacity of colon cancer cells.
TumCP↓,
lactateProd↓,
OCR↑, increase of oxygen consumption rate (OCR) both in normal colonic epithelial HCEC 1CT cells
ECAR↓, Following treatment with resveratrol (10 µM, 48 hr), the ECAR was unchanged in normal HCEC 1CT cells, whereas it was significantly reduced (31%) in HCEC 1CT RPA cells ****
*ECAR∅, Following treatment with resveratrol (10 µM, 48 hr), the ECAR was unchanged in normal HCEC 1CT cells
*other?, Resveratrol promotes a shift from respiration to glycolysis in cancer-like cells, but not in normal colonocytes
cycE/CCNE↑, Resveratrol inhibited cell cycle progression by enhancing the levels of cyclin E and cyclin A
cycA1/CCNA1↑,
TumCCA↑,
cycD1/CCND1↑, and by decreasing cyclin D1
OXPHOS↑, Taken together, these observations indicate that exposure to resveratrol leads to a metabolic reorientation from aerobic glycolysis toward OXPHOS.
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Human, |
GC, |
NA |
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in-vitro, |
GC, |
NCI-N87 |
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in-vitro, |
GC, |
SGC-7901 |
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other?, higher expression of xCT is associated with advanced tumour stage and poor overall survival of gastric cancer.
TumCP↓, Sulfasalazine can attenuate the proliferation, colony formation, metastasis and invasion of gastric cancer in vitro
TumMeta↓,
TumCI↓,
xCT↓, Sulfasalazine, a conventional drug, which is widely utilized in treating inflammatory diseases and rheumatoid arthritis, can also inhibit the expression and function of xCT
OS↑, higher xCT expression in gastric cancer under adjuvant chemotherapy possessed lower progression‐free survival and overall survival than patients with lower xCT expression,
*GSH↑, patients with ovarian cancer undergoing chemotherapy and receiving Se showed a significant increase in the activity of GSH-P(x) in erythrocytes after 2 months' (P < 0.0015) and 3 months' (P < 0.0038) supplementation.
*MDA↑, An increase of the concentration of malondialdehyde (MDA) following the administration of Se after 2 months (P < 0.0363) and 3 months (P < 0.0489) was found to be significant.
*other?, Se administration for 3 months resulted in the significant increase of white blood cells (WBC) (P < 0.0001)
*other?, After 2 and 3 months of Se administration, a significant decrease of hair loss
*chemoP↑, As a result of this clinical trial, we conclude that there are beneficial effects caused by ingesting selenium, as a supportive element in chemotherapy.
other?, see above for synethsis notes
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Study, |
AD, |
NA |
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Study, |
Park, |
NA |
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*Risk↓, Pantothenic acid was significantly decreased in the cerebellum (p = 0.008), substantia nigra (p = 0.02), and medulla (p = 0.008) of PDD cases.
*other↝, These findings have raised the question as to whether there may be common pathogenic insults present across multiple neurodegenerative diseases contributing to these similarities in presentation
*other↝, including widespread urea [12,13,14,15] and glucose increases [13,16,17,18], dysregulation of glucose and purine metabolism pathways [13,16,17,19,20], and decreases in the essential nutrient pantothenic acid [21,22], also known as vitamin B5.
*Ach↑, Pantothenic acid is essential for the synthesis of coenzyme A (CoA), a molecule with extensive roles in metabolism including in the tricarboxylic acid (TCA) cycle, fatty acid metabolism, and acetylcholine and myelin synthesis,
*Aβ↑, Interestingly though, an increased dietary intake of pantothenic acid has been associated with increased amyloid-β burden in individuals with cognitive impairment
*other?, This may indicate that pantothenic acid deficiencies in the brain cannot be counteracted by an increased dietary intake.
*Risk↓, We measured metabolic perturbations in HD-human brain in a case-control study, identifying pervasive lowering of vitamin B5
*neuroP↑, Pantothenate deficiency could lead to neurodegeneration/dementia in HD that might be preventable by treatment with vitamin B5.
*other?, Vitamin B5 is an essential trace nutrient that exists in the brain at concentrations of up to 50-fold those in plasma
*Ach↑, vitamin B5 participates via acetyl-CoA in the production of steroid hormones and acetylcholine in the brain
*other↝, resemble dementia or psychiatric disorders. Examples include deficiency of water soluble (B-group) vitamins including: thiamine (vitamin B1) [32]; niacin (vitamin B3) [33]; vitamin B6; folate (vitamin B9); [34] and cyanocobalamin (vitamin B12) [35]
*eff↓, However, treatment of common age-related dementias, such as that caused by AD, with preparations containing B-vitamins (folate and vitamin B12) has proven ineffectual [39].
*other↝, Our results point to a possible defect in the mechanism of cerebral uptake and/or storage of vitamin B5, consistent with its lowered concentrations in affected regions of HD brain.
Showing Research Papers: 1 to 21 of 21
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 21
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
Ferroptosis↑, 1, lipid-P↑, 1, OXPHOS↑, 1, ROS↓, 1, ROS↑, 1, xCT↓, 1,
Mitochondria & Bioenergetics ⓘ
ATP↑, 1, OCR↑, 1,
Core Metabolism/Glycolysis ⓘ
ECAR↓, 1, FAO↑, 1, Glycolysis↓, 1, homoC↓, 1, homoC↝, 1, lactateProd↓, 1, PDH↑, 1, PPP↓, 1, SCD1↓, 1,
Cell Death ⓘ
p‑Akt↓, 1, ASK1↑, 1, BAX↑, 1, Bcl-2↓, 1, Casp3↑, 1, Cyt‑c↝, 1, Ferroptosis↑, 1, JNK↑, 1, p‑p38↑, 1, survivin↓, 1, Telomerase↓, 1, TRPV1↑, 1,
Transcription & Epigenetics ⓘ
other?, 8, other↓, 1,
Protein Folding & ER Stress ⓘ
CHOP↑, 1, ER Stress↓, 1, GRP78/BiP↓, 1, HSP27↑, 1,
DNA Damage & Repair ⓘ
DNArepair↓, 1,
Cell Cycle & Senescence ⓘ
cycA1/CCNA1↑, 1, cycD1/CCND1↑, 1, cycE/CCNE↑, 1, P21↑, 1, TumCCA↑, 2,
Proliferation, Differentiation & Cell State ⓘ
ERK↑, 2, HDAC↓, 1, IGFBP3↑, 1, p‑PI3K↓, 1, TumCG↓, 1,
Migration ⓘ
Ca+2↑, 1, Ca+2↝, 1, FAK↓, 1, TumCI↓, 1, TumCP↓, 2, TumMeta↓, 2,
Angiogenesis & Vasculature ⓘ
angioG↓, 1, VEGF↓, 1,
Immune & Inflammatory Signaling ⓘ
Inflam↑, 1,
Hormonal & Nuclear Receptors ⓘ
AR↓, 1, CYP24A1↓, 1,
Drug Metabolism & Resistance ⓘ
ChemoSen↑, 2, Dose↝, 1, eff↑, 6, eff↝, 1, selectivity↑, 1,
Clinical Biomarkers ⓘ
AR↓, 1, GutMicro↑, 1,
Functional Outcomes ⓘ
Appetite↑, 1, chemoP↑, 1, cognitive↑, 1, OS↑, 1, Pain↓, 1, QoL↑, 1, radioP↑, 1, Sleep↑, 1, toxicity↓, 1,
Total Targets: 73
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 2, Catalase↑, 1, GPx↑, 1, GSH↑, 1, HO-1↑, 1, lipid-P↓, 1, MDA↑, 1, NRF2↑, 1, ROS↓, 3, ROS↑, 1, SOD↑, 2,
Core Metabolism/Glycolysis ⓘ
CYP3A4↑, 1, DHA↑, 1, ECAR∅, 1,
Transcription & Epigenetics ⓘ
Ach?, 1, Ach↑, 2, other?, 14, other↓, 1, other↑, 2, other↝, 9,
Migration ⓘ
AntiAg↑, 1, Ca+2↓, 1,
Barriers & Transport ⓘ
BBB↑, 2, P-gp↑, 1,
Immune & Inflammatory Signaling ⓘ
COX1↓, 1, IL4↓, 1, IL6↓, 1, Inflam↓, 1, TNF-α↓, 1,
Synaptic & Neurotransmission ⓘ
AChE↓, 1, BChE↓, 1,
Protein Aggregation ⓘ
Aβ↑, 1,
Drug Metabolism & Resistance ⓘ
Dose↝, 1, eff↓, 1, eff↑, 1,
Clinical Biomarkers ⓘ
IL6↓, 1,
Functional Outcomes ⓘ
chemoP↑, 1, cognitive↑, 1, memory↓, 1, Mood↑, 1, neuroP↑, 2, Risk↓, 2, Sleep↑, 1,
Total Targets: 43
Scientific Paper Hit Count for: other, other
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
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