FOXO3 Cancer Research Results

FOXO3, Forkhead Box O3: Click to Expand ⟱

Source:

Type:

FOXO3 (Forkhead Box O3) is a transcription factor that plays a critical role in regulating apoptosis, cell cycle arrest, DNA repair, and cellular stress responses.

• Positive Prognostic Marker
– In several cancers, higher nuclear FOXO3 expression (denoting active, transcriptionally functional FOXO3) is generally associated with a more favorable prognosis.
– Active FOXO3 can promote cell cycle arrest and apoptosis, thereby inhibiting tumor progression.

• Negative Prognostic Implications
– Conversely, reduced or cytoplasmically sequestered FOXO3 (often due to hyperactivation of the PI3K/Akt signaling pathway) has been linked to aggressive disease and poorer survival
– Loss of FOXO3 function can allow tumor cells to proliferate unchecked and resist apoptosis, which contributes to a worse outcome.

Scientific Papers found: Click to Expand⟱

2294-

Ba,

Baicalein attenuates cardiac hypertrophy in mice via suppressing oxidative stress and activating autophagy in cardiomyocytes

in-vivo,

Nor,

20–30 μM

mice. Cardiac hypertrophy was induced in mice by injection of isoproterenol (ISO, 30 mg·kg−1·d−1) for 15 days

*Catalase↑, *ROS↓, *cardioP↑, *FOXO3?,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Catalase↑, 1, ROS↓, 1,

Proliferation, Differentiation & Cell State ⓘ

FOXO3?, 1,

Functional Outcomes ⓘ

cardioP↑, 1,
Total Targets: 4

Scientific Paper Hit Count for: FOXO3, Forkhead Box O3

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells