Siegesbeckia glabrescens / NF-kB Cancer Research Results

GSL, Siegesbeckia glabrescens: Click to Expand ⟱

Features:

Germacranolide sesquiterpene lactone (GSL) was isolated from Siegesbeckia glabrescens as an inhibitor of Gli.

NF-kB, Nuclear factor kappa B: Click to Expand ⟱

Source: HalifaxProj(inhibit)

Type:

NF-kB signaling
Nuclear factor kappa B (NF-κB) is a transcription factor that plays a crucial role in regulating immune response, inflammation, cell proliferation, and survival.
NF-κB is often found to be constitutively active in many types of cancer cells. This persistent activation can promote tumorigenesis by enhancing cell survival, proliferation, and metastasis.

Scientific Papers found: Click to Expand⟱

7111-

GSL,

In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescens

NA,

Nor,

*NO↓, *PGE2↓, *iNOS↓, *COX2↓, *NF-kB↓, *Inflam↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Cell Death(tgid=5) ⓘ

iNOS↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1, Inflam↓, 1, NF-kB↓, 1, PGE2↓, 1,
Total Targets: 6

Scientific Paper Hit Count for: NF-kB, Nuclear factor kappa B

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells