tetrathiomolybdate / angioG Cancer Research Results

TM, tetrathiomolybdate: Click to Expand ⟱
Features:

Tetrathiomolybdate, often abbreviated TM, is a copper-chelating / copper-depleting agent. In cancer, it is mainly studied as an anti-angiogenic, anti-metastatic, tumor-microenvironment-modifying compound rather than as a conventional cytotoxic chemotherapy.
TM → copper depletion ↓ → angiogenesis ↓ / endothelial progenitor cells ↓ / LOX-family activity ↓ / SOD1 activity ↓ → metastasis support ↓
Tetrathiomolybdate binds copper and reduces biologically available copper.

Pathway / target Effect of tetrathiomolybdate Cancer relevance Notes
Copper bioavailability Decreases Anti-cancer TM binds copper and lowers biologically available copper needed by tumor-supporting enzymes.
Angiogenesis Decreases Anti-cancer Copper depletion reduces angiogenic support and may limit tumor vascularization.
Endothelial progenitor cells Decreases Anti-metastatic Relevant to high-risk breast cancer recurrence / tumor-microenvironment studies.
LOX / ECM remodeling Likely decreases through copper depletion Anti-invasive / anti-metastatic LOX-family enzymes are copper-dependent and contribute to extracellular-matrix remodeling and metastatic niche formation.
SOD1 Decreases, especially with ATN-224 Can increase tumor oxidative stress vulnerability This makes TM redox-active rather than a simple antioxidant.
Tumor dormancy May promote / maintain Potential anti-recurrence effect Most relevant where microscopic residual disease remains after standard therapy.
Gross tumor shrinkage Usually limited as monotherapy Weak direct cytotoxic effect Clinical signal appears stronger for stabilization or recurrence prevention than for tumor regression.


angioG, angiogenesis: Click to Expand ⟱
Source:
Type:
Process through which new blood vessels.
Angiogenesis, the process of new blood vessel formation from pre-existing vessels, plays a crucial role in cancer progression and metastasis. Tumors require a blood supply to grow beyond a certain size and to spread to other parts of the body.
Vascular Endothelial Growth Factor (VEGF): VEGF is one of the most important pro-angiogenic factors. It stimulates endothelial cell proliferation and migration, leading to the formation of new blood vessels. Many tumors overexpress VEGF, which correlates with poor prognosis.
Hypoxia-Inducible Factor (HIF): In response to low oxygen levels (hypoxia), tumors can activate HIF, which in turn promotes the expression of VEGF and other angiogenic factors. This mechanism allows tumors to adapt to their microenvironment and sustain growth.
Scientific Papers found: Click to Expand⟱
6174- TM,    Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse
- Trial, BC, NA
OS↑, toxicity↓, AntiTum↑, Copper↓, angioG↓,
6175- TM,    Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1
- vitro+vivo, Var, NA
SOD1↓, TumCP↓, angioG↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Copper↓, 1,   SOD1↓, 1,  

Migration ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,  

Functional Outcomes ⓘ

AntiTum↑, 1,   OS↑, 1,   toxicity↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: angioG, angiogenesis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:397  Target#:447  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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