tetrathiomolybdate / Copper Cancer Research Results

TM, tetrathiomolybdate: Click to Expand ⟱
Features:

Tetrathiomolybdate, often abbreviated TM, is a copper-chelating / copper-depleting agent. In cancer, it is mainly studied as an anti-angiogenic, anti-metastatic, tumor-microenvironment-modifying compound rather than as a conventional cytotoxic chemotherapy.
TM → copper depletion ↓ → angiogenesis ↓ / endothelial progenitor cells ↓ / LOX-family activity ↓ / SOD1 activity ↓ → metastasis support ↓
Tetrathiomolybdate binds copper and reduces biologically available copper.

Pathway / target Effect of tetrathiomolybdate Cancer relevance Notes
Copper bioavailability Decreases Anti-cancer TM binds copper and lowers biologically available copper needed by tumor-supporting enzymes.
Angiogenesis Decreases Anti-cancer Copper depletion reduces angiogenic support and may limit tumor vascularization.
Endothelial progenitor cells Decreases Anti-metastatic Relevant to high-risk breast cancer recurrence / tumor-microenvironment studies.
LOX / ECM remodeling Likely decreases through copper depletion Anti-invasive / anti-metastatic LOX-family enzymes are copper-dependent and contribute to extracellular-matrix remodeling and metastatic niche formation.
SOD1 Decreases, especially with ATN-224 Can increase tumor oxidative stress vulnerability This makes TM redox-active rather than a simple antioxidant.
Tumor dormancy May promote / maintain Potential anti-recurrence effect Most relevant where microscopic residual disease remains after standard therapy.
Gross tumor shrinkage Usually limited as monotherapy Weak direct cytotoxic effect Clinical signal appears stronger for stabilization or recurrence prevention than for tumor regression.


Copper, Copper: Click to Expand ⟱
Source:
Type:
Copper is an essential trace element that plays a critical role in various biological processes, including iron metabolism, energy production, and the functioning of the immune system. However, its relationship with cancer is complex, as both copper deficiency and excess can influence cancer development and progression.
Many cancer cells exhibit elevated levels of copper compared to normal cells. This accumulation can support tumor growth and metastasis by:
Enhancing angiogenesis (the formation of new blood vessels).
Promoting cell proliferation and survival.
Supporting the activity of copper-dependent enzymes that facilitate tumor progression. Copper and Oxidative Stress: While copper is essential for antioxidant enzymes, excess copper can lead to the generation of reactive oxygen species (ROS), contributing to oxidative stress.
Elevated copper levels can promote inflammation and support the growth of tumors.
Copper Chelation Therapy: Given the role of copper in cancer progression, copper chelation (the use of agents that bind copper and promote its excretion) has been explored as a potential therapeutic strategy.
Scientific Papers found: Click to Expand⟱
6172- TM,    Phase II trial of copper depletion with tetrathiomolybdate as an antiangiogenesis strategy in patients with hormone-refractory prostate cancer
- Trial, Pca, NA
Copper↓, angioG∅, eff∅,
6174- TM,    Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse
- Trial, BC, NA
OS↑, toxicity↓, AntiTum↑, Copper↓, angioG↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Copper↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   angioG∅, 1,  

Drug Metabolism & Resistance ⓘ

eff∅, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   OS↑, 1,   toxicity↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Copper, Copper
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:397  Target#:65  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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