Radicicol/monorden / MMPs Cancer Research Results

Radic, Radicicol/monorden: Click to Expand ⟱
Features: HSP90 inhibitor

Radicicol, also known as monorden, is a fungal resorcylic acid lactone and natural-product HSP90 inhibitor. It binds the N-terminal ATP-binding pocket of HSP90 and inhibits its molecular-chaperone activity, resulting in destabilization and degradation of HSP90-dependent client proteins involved in tumour growth and survival. Reported effects include suppression of oncogenic kinase signalling, cell-cycle arrest, and apoptosis in experimental cancer models. Although radicicol is potent in biochemical and cell-based assays, the native compound has limited therapeutic utility because of chemical instability, rapid metabolism, and weak in-vivo activity. Reference.



MMPs, Matrix metalloproteinases: Click to Expand ⟱
Source:
Type:
Family of zinc-dependent proteolytic enzymes that play a key role in degrading the extracellular matrix (ECM).; are metalloproteinases that are calcium-dependent zinc-containing endopeptidases;[1] other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.[2]
MMP secretion: matrix metalloproteinase (MMP) is a kind of enzymes secreted.
by tumor cell to degrade ECM, facilitating the migration of tumor cells.

MMPs are generally considered protumorigenic due to their role in promoting tumor invasion, metastasis, and angiogenesis. They facilitate the breakdown of the extracellular matrix, allowing cancer cells to invade surrounding tissues and spread to distant sites.
Scientific Papers found: Click to Expand⟱
6918- FIS,  Geld,  Radic,    HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells
- in-vitro, CRC, COLO205
eff↑, cl‑Casp3↑, PARP↑, MMPs↓, cl‑Casp9↑, other↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

cl‑Casp3↑, 1,   cl‑Casp9↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↑, 1,  

Migration(tgid=13) ⓘ

MMPs↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MMPs, Matrix metalloproteinases
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:423  Target#:204  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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