Isoliquiritigenin / Bcl-2 Cancer Research Results

ISL, Isoliquiritigenin: Click to Expand ⟱

Features:

ISL is a distinct natural chalcone, chemically identified as 2′,4′,4-trihydroxychalcone, found particularly in licorice species such as Glycyrrhiza spp.ISL has substantial preclinical evidence involving anticancer, anti-inflammatory, antioxidant, metabolic, and neuroprotective effects. Reported anticancer actions include inhibition of proliferation, angiogenesis, EMT, invasion, and metastasis, with induction of apoptosis, cell-cycle arrest, autophagy, or ferroptosis depending on the model. Frequently reported pathways include PI3K/AKT/mTOR, NF-κB, STAT3, MAPK, Wnt/β-catenin, Nrf2, and Src signalling.

Bcl-2, B-cell CLL/lymphoma 2: Click to Expand ⟱

Source: HalifaxProj (inhibit) CGL-Driver Genes

Type: Antiapoptotic Oncogene

The proteins of BCL-2 family are classified into three subgroups, i.e., the anti-apoptotic/pro-survival proteins represented by BCL-2 and BCL-XL, the pro-apoptotic proteins represented by BAX and Bak, and the pro-apoptotic BH3-only proteins represented by BAD and BID.
Since the expression of Bcl-2 protein in tumor cells is much higher than that in normal cells, inhibitors targeting it have little effect on normal cells.

Scientific Papers found: Click to Expand⟱

6993-

Form,

ISL,

Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell

in-vitro,

CRC,

HCT116

AntiTum↑, TumCG↓, Apoptosis↑, Casp↑, Bcl-2↓, Bcl-xL↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1, Bcl-2↓, 1, Bcl-xL↓, 1, Casp↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Bcl-2, B-cell CLL/lymphoma 2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells