epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione / STAT3 Cancer Research Results

HDN-1, epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione: Click to Expand ⟱
Features:

HDN-1 is a naturally occurring fungal epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione (ETP) isolated from the Antarctic fungus Oidiodendron truncatum GW3-13. HDN-1 has demonstrated preclinical anticancer activity and acts as a direct Hsp90 inhibitor, binding the C-terminal region of Hsp90α. Hsp90 inhibition by HDN-1 promotes degradation of multiple oncogenic client proteins, enhances downregulation of wild-type and mutant EGFR and suppresses tumour-cell proliferation. HDN-1 has also induced differentiation followed by apoptosis in selected promyelocytic leukemia cell lines. Its mechanism overlaps with that of the structurally related ETP chaetocin, which also inhibits Hsp90, but HDN-1 and chaetocin are chemically distinct compounds and should be maintained as separate products. HDN-1 should be classified as an experimental natural fungal metabolite / epipolythiodioxopiperazine / Hsp90 inhibitor, with current anticancer evidence predominantly preclinical.
HDN-1 is an analogue of chaetocin, which is a fungal mycotoxin with histone methyltransferase SUV39H1 inhibitory activity
STAT3, Signal transducer and activator of transcription 3: Click to Expand ⟱
Source:
Type: Oncogene
Stat3 (Signal Transducer and Activator of Transcription 3) is a transcription factor that plays a crucial role in various cellular processes, including cell growth, survival, differentiation, and immune response.
Stat3 is frequently found to be constitutively activated in many types of cancers, including breast, prostate, lung, and head and neck cancers. (associated with poor prognosis and reduced survival.)

-STAT3 is typically activated by cytokines (such as IL-6) and growth factors binding to their respective receptors.
-Activated STAT3 upregulates the expression of genes that promote cell cycle progression (e.g., cyclin D1) and anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL).
Scientific Papers found: Click to Expand⟱
7169- HDN-1,  CHA,    Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90
- in-vitro, Lung, H1975 - in-vitro, Lung, HCC827 - in-vitro, Lung, A549
HSP90↓, TumCP↓, EGFR↓, STAT3↓, Akt↓, ERK↓, Raf↓, cycD1/CCND1↓, SUV39H↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

SUV39H↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Raf↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGFR↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: STAT3, Signal transducer and activator of transcription 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:434  Target#:373  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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