epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione / Akt Cancer Research Results

HDN-1, epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione: Click to Expand ⟱
Features:

HDN-1 is a naturally occurring fungal epipolythiodioxopiperazine / epipolythiopiperazine-2,5-dione (ETP) isolated from the Antarctic fungus Oidiodendron truncatum GW3-13. HDN-1 has demonstrated preclinical anticancer activity and acts as a direct Hsp90 inhibitor, binding the C-terminal region of Hsp90α. Hsp90 inhibition by HDN-1 promotes degradation of multiple oncogenic client proteins, enhances downregulation of wild-type and mutant EGFR and suppresses tumour-cell proliferation. HDN-1 has also induced differentiation followed by apoptosis in selected promyelocytic leukemia cell lines. Its mechanism overlaps with that of the structurally related ETP chaetocin, which also inhibits Hsp90, but HDN-1 and chaetocin are chemically distinct compounds and should be maintained as separate products. HDN-1 should be classified as an experimental natural fungal metabolite / epipolythiodioxopiperazine / Hsp90 inhibitor, with current anticancer evidence predominantly preclinical.
HDN-1 is an analogue of chaetocin, which is a fungal mycotoxin with histone methyltransferase SUV39H1 inhibitory activity
Akt, PKB-Protein kinase B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes; Akt2 is an important signaling molecule in the insulin signaling pathway. It is required to induce glucose transport.

Inhibitors:
-Curcumin: downregulate AKT phosphorylation and signaling.
-Resveratrol
-Quercetin: inhibit the PI3K/AKT pathway.
-Epigallocatechin Gallate (EGCG)
-Luteolin and Apigenin: inhibit AKT phosphorylation


Scientific Papers found: Click to Expand⟱
7169- HDN-1,  CHA,    Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90
- in-vitro, Lung, H1975 - in-vitro, Lung, HCC827 - in-vitro, Lung, A549
HSP90↓, TumCP↓, EGFR↓, STAT3↓, Akt↓, ERK↓, Raf↓, cycD1/CCND1↓, SUV39H↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

SUV39H↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Raf↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGFR↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Akt, PKB-Protein kinase B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:434  Target#:4  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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