Ginkgolic acids / lipoGen Cancer Research Results

GAs, Ginkgolic acids: Click to Expand ⟱
Features:

Ginkgolic acids (GAs) are a group of naturally occurring 2-hydroxy-6-alkylsalicylic acids found in Ginkgo biloba leaves, seeds and especially the seed coat. Major congeners include ginkgolic acid C13:0, C15:1 and C17:1. Ginkgolic acids have demonstrated antimicrobial, antiviral, autophagy-modulating and anticancer activities in preclinical studies. In cancer models, GAs can suppress proliferation, migration and invasion and promote apoptosis through mechanisms including inhibition of SUMOylation, STAT3 signalling, Hsp90 activity and other oncogenic pathways. Individual congeners can differ substantially in potency and biological activity, so specific forms such as C15:1 or C17:1 should be recorded separately when identified. Ginkgolic acids are kept separate from standardized Ginkgo biloba extracts because they are considered potentially toxic constituents and are deliberately reduced to very low concentrations in purified medicinal ginkgo preparations. Current anticancer evidence is predominantly preclinical.



lipoGen, lipogenesis: Click to Expand ⟱
Source:
Type:
Lipogenesis is the metabolic process by which simple substrates like acetyl-CoA are converted into fatty acids, which are then assembled into complex lipids. This process is essential for producing cell membranes, signaling molecules, and energy storage forms, such as triglycerides. In normal physiology, lipogenesis is tightly regulated by nutritional and hormonal signals to meet the needs of different tissues.
Key enzymes (e.g. acetyl-CoA carboxylase [ACC], fatty acid synthase [FASN]) involved in lipogenesis. Several enzymes play critical roles in lipogenesis, including acetyl-CoA carboxylase (ACC), which catalyzes the rate-limiting formation of malonyl-CoA, and fatty acid synthase (FASN), which catalyzes the assembly of fatty acids. Transcription factors such as SREBP1 (sterol regulatory element-binding protein 1) also regulate the expression of lipogenic genes.

Cancer cells often upregulate lipogenesis, even under conditions where normal cells might rely on dietary fat. This metabolic reprogramming supports rapid cell proliferation by providing the necessary lipids for new cellular membranes and energy storage. Elevated activity of enzymes like ACC and FASN is frequently observed in tumors.
High lipogenic activity in tumors has been correlated with aggressive phenotypes. Elevated expression of lipogenic enzymes is often associated with increased cell proliferation, invasion, and resistance to apoptosis. Consequently, tumors showing robust lipogenesis may be linked to poorer overall prognosis.
Scientific Papers found: Click to Expand⟱
1186- GAs,    Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis
- in-vitro, PC, NA - in-vitro, Nor, HUVECs - in-vivo, PC, NA
tumCV↓, *toxicity∅, TumCMig↓, TumCI↓, Apoptosis↑, AMPK↑, lipoGen↓, ACC↓, FASN↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   AMPK↑, 1,   FASN↓, 1,   lipoGen↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity∅, 1,  
Total Targets: 1

Scientific Paper Hit Count for: lipoGen, lipogenesis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:436  Target#:1038  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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