Ginkgolic acids / PAI-1/SERPINE1 Cancer Research Results

GAs, Ginkgolic acids: Click to Expand ⟱

Features:

Ginkgolic acids (GAs) are a group of naturally occurring 2-hydroxy-6-alkylsalicylic acids found in Ginkgo biloba leaves, seeds and especially the seed coat. Major congeners include ginkgolic acid C13:0, C15:1 and C17:1. Ginkgolic acids have demonstrated antimicrobial, antiviral, autophagy-modulating and anticancer activities in preclinical studies. In cancer models, GAs can suppress proliferation, migration and invasion and promote apoptosis through mechanisms including inhibition of SUMOylation, STAT3 signalling, Hsp90 activity and other oncogenic pathways. Individual congeners can differ substantially in potency and biological activity, so specific forms such as C15:1 or C17:1 should be recorded separately when identified. Ginkgolic acids are kept separate from standardized Ginkgo biloba extracts because they are considered potentially toxic constituents and are deliberately reduced to very low concentrations in purified medicinal ginkgo preparations. Current anticancer evidence is predominantly preclinical.

PAI-1/SERPINE1, plasminogen activator inhibitor-1: Click to Expand ⟱

Source:

Type:

PAI-1 (plasminogen activator inhibitor-1; SERPINE1) is a secreted serine-protease inhibitor that primarily inhibits tissue-type and urokinase-type plasminogen activators (tPA/PLAT and uPA/PLAU), thereby regulating plasmin generation, fibrinolysis and extracellular-matrix remodeling. In many cancers, PAI-1 is overexpressed by tumour cells and stromal cells and can promote tumour-cell survival, migration, invasion, angiogenesis, epithelial–mesenchymal transition, metastasis and resistance to therapy through both protease-dependent and signalling functions involving interactions with vitronectin, integrins and LRP1. High tumour or circulating PAI-1 is associated with poor prognosis in several malignancies, particularly breast cancer. The typical cancer-associated direction is therefore generally up, while the desired anticancer modulation is commonly down or functional inhibition. PAI-1 is also strongly associated with cellular senescence and is frequently used as a component of the senescence-associated secretory phenotype (SASP), although elevated PAI-1 alone is not sufficient to establish cellular senescence. PAI-1 is kept separate from PAI-2/SERPINB2 and from its upstream plasminogen activators uPA and tPA.

In cancer, PAI-1 is commonly upregulated and is associated with invasion, angiogenesis, metastasis, treatment resistance, and poor prognosis, although its biology is context-dependent.

Scientific Papers found: Click to Expand⟱

7224-

GAs,

Ginkgolic acids inhibit migration in breast cancer cells by inhibition of NEMO sumoylation and NF-κB activity

in-vitro,

BC,

MCF7

in-vitro,

BC,

MDA-MB-231

Wound Healing↓, uPA↓, PAI-1/SERPINE1↓, CXCR4↓, MMP9↓, TumCMig↓, NF-kB↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Migration(tgid=13) ⓘ

MMP9↓, 1, PAI-1/SERPINE1↓, 1, TumCMig↓, 1, uPA↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CXCR4↓, 1, NF-kB↓, 1,

Functional Outcomes(tgid=23) ⓘ

Wound Healing↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: PAI-1/SERPINE1, plasminogen activator inhibitor-1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells