Ginkgolic acids / MMP9 Cancer Research Results

GAs, Ginkgolic acids: Click to Expand ⟱
Features:

Ginkgolic acids (GAs) are a group of naturally occurring 2-hydroxy-6-alkylsalicylic acids found in Ginkgo biloba leaves, seeds and especially the seed coat. Major congeners include ginkgolic acid C13:0, C15:1 and C17:1. Ginkgolic acids have demonstrated antimicrobial, antiviral, autophagy-modulating and anticancer activities in preclinical studies. In cancer models, GAs can suppress proliferation, migration and invasion and promote apoptosis through mechanisms including inhibition of SUMOylation, STAT3 signalling, Hsp90 activity and other oncogenic pathways. Individual congeners can differ substantially in potency and biological activity, so specific forms such as C15:1 or C17:1 should be recorded separately when identified. Ginkgolic acids are kept separate from standardized Ginkgo biloba extracts because they are considered potentially toxic constituents and are deliberately reduced to very low concentrations in purified medicinal ginkgo preparations. Current anticancer evidence is predominantly preclinical.



MMP9, MMP9: Click to Expand ⟱
Source: HalifaxProj(suppress)
Type:
Matrix metalloproteinase-9 (MMP-9) is an enzyme that plays a significant role in the degradation of extracellular matrix components.
MMP-9 facilitates the breakdown of the extracellular matrix, which can enable cancer cells to invade surrounding tissues and spread to distant sites (metastasis).
Elevated levels of MMP-9 have been associated with poor prognosis in several cancers, including breast, lung, and colorectal cancers.
MMP2 and MMP9: two enzymes are critical to tumor invasion.
Scientific Papers found: Click to Expand⟱
7213- GAs,    Anti-Cancer Properties of Ginkgolic Acids in Human Nasopharyngeal Carcinoma CNE-2Z Cells via Inhibition of Heat Shock Protein 90
- vitro+vivo, NPC, CNE2 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Lung, H1975
ATPase↓, HSP90↓, TumCP↓, *toxicity↝, MMP2↓, MMP9↓, HER2/EBBR2↓, c-Raf↓, Akt↓, Bcl-2↓, other↝,
7224- GAs,    Ginkgolic acids inhibit migration in breast cancer cells by inhibition of NEMO sumoylation and NF-κB activity
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
Wound Healing↓, uPA↓, PAI-1/SERPINE1↓, CXCR4↓, MMP9↓, TumCMig↓, NF-kB↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

c-Raf↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Bcl-2↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Migration(tgid=13) ⓘ

ATPase↓, 1,   MMP2↓, 1,   MMP9↓, 2,   PAI-1/SERPINE1↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   uPA↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CXCR4↓, 1,   NF-kB↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

HER2/EBBR2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Wound Healing↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↝, 1,  
Total Targets: 1

Scientific Paper Hit Count for: MMP9, MMP9
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:436  Target#:203  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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