Ginkgo biloba-EGb 761 / Casp9 Cancer Research Results

EGb 761, Ginkgo biloba-EGb 761: Click to Expand ⟱

Features:

<p>
<strong>EGb 761</strong> is a standardized, purified extract of
<em>Ginkgo biloba</em> leaves developed for medicinal use. It is typically
standardized to approximately <strong>22–27% flavone glycosides</strong> and
<strong>5–7% terpene lactones</strong>, including ginkgolides A, B and C and
bilobalide, while potentially undesirable <strong>ginkgolic acids</strong> are
reduced to very low levels. EGb 761 has antioxidant, mitochondrial,
neuroprotective, vasoregulatory, anti-inflammatory and platelet-activating-factor
antagonist effects and has been studied extensively in cognitive impairment,
dementia and Alzheimer’s disease. Reported mechanisms include reduction of
oxidative stress, stabilization of mitochondrial function, modulation of
neurotransmitter signalling, protection against amyloid-β-associated toxicity,
improved cerebral microcirculation and modulation of inflammatory pathways.
EGb 761 is kept separate from generic <em>Ginkgo biloba</em> supplements
because commercial extracts vary substantially in flavonoid, terpene-lactone
and ginkgolic-acid content and are not necessarily pharmacologically equivalent
to the standardized EGb 761 preparation. EGb 761 is kept separate
from isolated ginkgolides, bilobalide and ginkgolic acids 
</p>

<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12417213/">high PCA content in EGb 761 may contribute to cognitive benefits</a><br>
 bioactive compounds such as terpenoids (Ginkgolides A, B, and C), polyphenols, organic acids, and flavonoids (quercetin, kaempferol, and isorhamnetin). <br>

<a href="https://pubmed.ncbi.nlm.nih.gov/22784423/">EGb 761</a> 
is a dry extract from Ginkgo biloba leaves (35–67:1), extraction solvent acetone
60% (w/w). The extract is adjusted to 22.0–27.0% ginkgo flavonoids and 5.0–7.0% terpene lactones,
consisting of 2.8–3.4% ginkgolides A, B, and C and 2.6–3.2% bilobalide and contains less than 5 ppm
ginkgolic acids<br>

<pre>


Table 1. Protective capacity of individual compounds of EGb 761 in brain cells)
COMPOUNDMEAN (SEM) PROTECTION ( % )
(0.5 mg/ml) (percentage recovery after insult)
Ginkgolide A    8.0±1.9∗∗
Ginkgolide B    33.0±11.2∗
Ginkgolide C    8.5±1.6∗∗
Ginkgolide J    37.0±12.2∗
Bilobalide      36.3±7.7∗∗
Flavonoids      56.4±12.7∗∗∗
</pre>

Casp9, Caspase-9: Click to Expand ⟱

Source:

Type:

Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspase-9:
Role: Initiator caspase in the intrinsic apoptotic pathway.
Cancers: Frequently studied in leukemia and solid tumors.
Prognosis: Reduced expression is often linked to chemoresistance and poor prognosis.

Scientific Papers found: Click to Expand⟱

7208-

EGb 761,

EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line

in-vitro,

Nor,

SH-SY5Y

pentylenetetrazole treatment in a neuroblastoma cell line

*Ca+2↑, *Apoptosis↓, *ROS↓, *MMP↑, *Casp3↓, *Casp9↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Migration(tgid=13) ⓘ

Ca+2↑, 1,
Total Targets: 6

Scientific Paper Hit Count for: Casp9, Caspase-9

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:438  Target#:45  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

Ginkgo biloba-EGb 761 / Casp9 Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Cell Death(tgid=5) ⓘ

Migration(tgid=13) ⓘ

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