Isobavachalcone / DHODH Cancer Research Results

IBC, Isobavachalcone: Click to Expand ⟱
Features:

Isobavachalcone - Prenylated Chalcone

Type: Natural prenylated chalcone / flavonoid-related phytochemical
-Chalcone → chemical class / parent scaffold, not a molecular target. -Example Chalones: Isobavachalcone, xanthohumol, licochalcone A, isoliquiritigenin

Sources: Found in several medicinal plants, particularly Psoralea corylifolia (Cullen corylifolium), as well as other plant species containing prenylated chalcones.

Function: Isobavachalcone is a bioactive prenylated chalcone with anticancer, anti-inflammatory, antioxidant, antimicrobial, and neuroprotective activities. Reported molecular effects include modulation of AKT, ERK/MAPK, ROS, apoptosis, inflammatory signaling, and cellular stress pathways.

Cancer: Experimental studies demonstrate inhibition of cancer-cell proliferation, migration, and invasion and induction of apoptosis and other forms of regulated cell death. IBC can suppress AKT and ERK signaling, increase tumor-cell oxidative stress, and modulate antitumor immune responses. Anticancer activity has been demonstrated in pancreatic, breast, oral, colorectal, thyroid, and other experimental cancer models.

Alzheimer's Disease: Preclinical studies indicate neuroprotective activity, including reduction of Aβ accumulation and plaque pathology, suppression of neuroinflammation, and improvement of memory and cognitive deficits in Alzheimer's disease models.
DHODH, Dihydroorotate Dehydrogenase: Click to Expand ⟱
Source:
Type:

DHODH - Dihydroorotate Dehydrogenase

Type: Mitochondrial enzyme / de novo pyrimidine synthesis enzyme

Function: Inner mitochondrial membrane enzyme that catalyzes the oxidation of dihydroorotate to orotate, a rate-limiting step in de novo pyrimidine nucleotide synthesis. DHODH transfers electrons to coenzyme Q and links pyrimidine synthesis with mitochondrial respiration, redox regulation, proliferation, and cellular metabolic adaptation.

Cancer: ↑ Frequently increased or functionally required in rapidly proliferating cancer cells to maintain pyrimidine nucleotide synthesis and tumor growth. DHODH inhibition can suppress proliferation, induce differentiation, impair mitochondrial metabolism, and enhance cancer-cell susceptibility to ferroptosis and other anticancer therapies.
Scientific Papers found: Click to Expand⟱
7385- IBC,    Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction
- vitro+vivo, Lung, A549 - in-vitro, BC, 4T1
Apoptosis↑, necrosis↑, ROS↑, mtDam↑, Ca+2↑, MPT↑, MMP↓, AntiCan↑, *AntiBio↑, *Inflam↓, *antiOx↓, *neuroP↑, p‑Akt↓, DHODH↓, Diff↑, MAPK↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

DHODH↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   MPT↑, 1,   mtDam↑, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   MAPK↑, 1,   necrosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: DHODH, Dihydroorotate Dehydrogenase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:446  Target#:1634  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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