Vitexin / GFAP Cancer Research Results

VT, Vitexin: Click to Expand ⟱
Features:

Vitexin - Apigenin-8-C-Glucoside

Alternative Names: Apigenin-8-C-glucoside, apigenin-8-C-β-D-glucopyranoside

Type: Flavone C-glycoside / apigenin derivative

Function: Vitexin is a naturally occurring C-glycosylated flavone in which glucose is attached to apigenin at the C-8 position. It exhibits antioxidant, anti-inflammatory, metabolic, cardiovascular, neuroprotective, and antiproliferative activities and can modulate pathways involving NF-κB, Nrf2/HO-1, MAPK, PI3K/AKT, AMPK, HIF-1α, apoptosis, and oxidative stress.

-see also IsoVitexin

Cancer: Preclinical studies indicate antiproliferative, pro-apoptotic, anti-migratory, anti-invasive, and anti-inflammatory effects across multiple cancer models. Reported mechanisms include modulation of PI3K/AKT, MAPK, NF-κB, HIF-1α, ROS, apoptosis, and cell-cycle signaling. Clinical anticancer efficacy has not been established.

Alzheimer's Disease: Preclinical evidence suggests neuroprotective activity through antioxidant and anti-inflammatory effects, reduction of neuronal injury, regulation of oxidative stress and mitochondrial function, and modulation of signaling pathways relevant to cognitive impairment and amyloid-associated neurotoxicity. Clinical efficacy for Alzheimer's disease has not been established.
GFAP, Glial Fibrillary Acidic Protein: Click to Expand ⟱
Source:
Type: biomarker

GFAP - Glial Fibrillary Acidic Protein

Type: Intermediate filament protein / astrocyte marker / reactive astrogliosis biomarker

Function: GFAP is a type III intermediate filament protein expressed predominantly in astrocytes. It contributes to astrocyte cytoskeletal structure, mechanical stability, cellular remodeling, and responses to central nervous system injury. Increased GFAP expression is widely used as a marker of reactive astrocyte activation and astrogliosis.

Cancer: ↕ Context-dependent. GFAP is widely used as a marker of astrocytic differentiation in gliomas and astrocytomas, but total GFAP expression does not show a uniform relationship with tumor aggressiveness. Changes in GFAP isoforms, particularly the GFAPδ/GFAPα ratio, may be associated with more malignant astrocytoma phenotypes.

Alzheimer's Disease: ↑ Increased GFAP reflects reactive astrogliosis associated with Alzheimer's disease pathology. Elevated GFAP is observed in affected brain regions and increased circulating GFAP is strongly associated with cerebral amyloid pathology and progression toward cognitive impairment.
Scientific Papers found: Click to Expand⟱
7902- VT,    Vitexin Protects Against Scopolamine-Induced Cognitive Impairment by Preserving Synaptic Integrity and Modulating Nrf2/HO-1 and NF-κB Signaling Pathways
- in-vivo, AD, NA
*Dose↝, *Learn↑, *memory↑, *AChE↓, *lipid-P↓, *TOS↓, *MDA↓, *ONOO↓, *NO↓, *NOS2↓, *TAC↑, *BDNF↑, *GDNF↑, *PSD95↑, *GFAP↓, *NF-kB↓, *COX2/PTGS2↓, *NRF2↑, *HO-1↑, *neuroP↑, *NeuroI↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

GDNF↑, 1,   GFAP↓, 1,   Learn↑, 1,   NeuroI↓, 1,   ONOO↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 1,   TAC↑, 1,   TOS↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   NF-kB↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 1,   PSD95↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

NOS2↓, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 1,   neuroP↑, 1,  
Total Targets: 21

Scientific Paper Hit Count for: GFAP, Glial Fibrillary Acidic Protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:462  Target#:1647  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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