Vitexin / Inflam Cancer Research Results

VT, Vitexin: Click to Expand ⟱
Features:

Vitexin - Apigenin-8-C-Glucoside

Alternative Names: Apigenin-8-C-glucoside, apigenin-8-C-β-D-glucopyranoside

Type: Flavone C-glycoside / apigenin derivative

Function: Vitexin is a naturally occurring C-glycosylated flavone in which glucose is attached to apigenin at the C-8 position. It exhibits antioxidant, anti-inflammatory, metabolic, cardiovascular, neuroprotective, and antiproliferative activities and can modulate pathways involving NF-κB, Nrf2/HO-1, MAPK, PI3K/AKT, AMPK, HIF-1α, apoptosis, and oxidative stress.

-see also IsoVitexin

Cancer: Preclinical studies indicate antiproliferative, pro-apoptotic, anti-migratory, anti-invasive, and anti-inflammatory effects across multiple cancer models. Reported mechanisms include modulation of PI3K/AKT, MAPK, NF-κB, HIF-1α, ROS, apoptosis, and cell-cycle signaling. Clinical anticancer efficacy has not been established.

Alzheimer's Disease: Preclinical evidence suggests neuroprotective activity through antioxidant and anti-inflammatory effects, reduction of neuronal injury, regulation of oxidative stress and mitochondrial function, and modulation of signaling pathways relevant to cognitive impairment and amyloid-associated neurotoxicity. Clinical efficacy for Alzheimer's disease has not been established.
Inflam, inflammation: Click to Expand ⟱
Source:
Type:
Cancer and inflammation are closely linked, with chronic inflammation contributing to the development and progression of cancer. Various inflammatory mediators and cells are involved in this process.
Scientific Papers found: Click to Expand⟱
7891- IVT,  VT,    Effects of C-glycosylation on anti-diabetic, anti-Alzheimer's disease and anti-inflammatory potential of apigenin
- NA, AD, NA
*AntiDiabetic↑, *Inflam↓, *AGEs↓, *AChE↓, *BChE↓, *PTP1B↓,
7824- MBS,  IVT,  VT,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA - Review, Stroke, NA - Review, Park, NA
*neuroP↑, *Aβ↓, *p‑tau↓, *ROS↓, *Inflam↓, *AChE↓, *BBB↑, *memory↑, *hepatoP↑, *Imm↑, *hyperG↓, *AntiCan↑, *eff↑, *Stroke↓, *BACE/β-secretase↓, *PI3K↓, *Akt↓, *mTOR↓, *Dose↓,
7916- VT,    Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway
- in-vitro, HCC, NA
*antiOx↑, *Inflam↓, *AntiTum↑, Apoptosis↑, Casp3↑, Bcl-2↓, LC3II↓, p‑JNK↑, p‑ERK↓,
7915- VT,    A Brief Review on the Neuroprotective Mechanisms of Vitexin
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *cognitive↓, *motorD↑, *BACE/β-secretase↓, *LDH↓, *AChE↓, *BChE↓, *ROS↓,
7913- VT,    Review of the effects of vitexin in oxidative stress-related diseases
*antiOx↑, *ROS↓, *lipid-P↓, *memory↑, *Stroke↓, *cardioP↑, *neuroP↑, *Inflam↓, *NRF2↑, *HO-1↑, *NQO1↑, *GRP78/BiP↑, *CHOP/DDIT3↓, *BACE/β-secretase↓, *ChE↓, *AChE↓, *BChE↓, *GSH↑, *TNF-α↓, *IL1β↓, *IL6↓, *IL33↓, *LDH↓, *MDA↓, *SOD↑,
7887- VT,  IVT,    Dietary Flavonoids Vitexin and Isovitexin: New Insights into Their Functional Roles in Human Health and Disease Prevention
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Bacteria↓, *neuroP↑, *Obesity↓, *cardioP↑, *ROS↓, *MMP↑, *ATP↑, *MFN2↑, *DRP1/DNM1L↓, *FOXO3↑, *NRF2↑, *Ferroptosis↓, *GPx4↑, TumCP↓, HMGB1↓, PI3K↓, Akt↓, Hif1a↓, CDK1↓, CycB/CCNB1↓, TumCCA↑, Apoptosis↑, P53↑, NF-kB↓, ERK↓, p‑PI3K↓, miR-34a↑, Apoptosis↑, CSCs?, *MAPK↓, *HO-1↑, *hepatoP↑, *AMPK↑, *Akt↑, *GSK‐3β↑, *chemoP↑, *Casp3↓, *IRes↝, *GlucoseCon↑, ChemoSen↑, *GSH↑, *SOD↑, *ATF2↑, *GPx↑, *GSTs↑, *AntiAge↑, *Stroke↓, *AChE↓, *ACE/ACE1↓, *ACE2↓, *GutMicro↑, *MPO↓, *H+/K+-ATPase↓, *AntiDiabetic↑, *GLUT4↑, *Obesity↓, *HH↓, *RenoP↑, *BioAv↓, *BioAv↝, *BioAv↑,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 3,   Bcl-2↓, 1,   Casp3↑, 1,   p‑JNK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CycB/CCNB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs?, 1,   ERK↓, 1,   p‑ERK↓, 1,   miR-34a↑, 1,   PI3K↓, 1,   p‑PI3K↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 1,   ACE2↓, 1,   H+/K+-ATPase↓, 1,   IRes↝, 1,   Stroke↓, 3,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Ferroptosis↓, 1,   GPx↑, 1,   GPx4↑, 1,   GSH↑, 2,   GSTs↑, 1,   HO-1↑, 2,   hyperG↓, 1,   lipid-P↓, 1,   MDA↓, 1,   MFN2↑, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↑, 2,   ROS↓, 4,   SOD↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   DRP1/DNM1L↓, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   GlucoseCon↑, 1,   LDH↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   ATF2↑, 1,   Casp3↓, 1,   Ferroptosis↓, 1,   MAPK↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   GRP78/BiP↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXO3↑, 1,   GSK‐3β↑, 1,   HH↓, 1,   mTOR↓, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

PTP1B↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL33↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 6,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 5,   BChE↓, 3,   ChE↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,   BACE/β-secretase↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   Dose↓, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,   IL6↓, 1,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 2,   AntiDiabetic↑, 2,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 1,   cognitive↓, 1,   hepatoP↑, 2,   memory↑, 2,   motorD↑, 1,   neuroP↑, 4,   Obesity↓, 2,   RenoP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 78

Scientific Paper Hit Count for: Inflam, inflammation
6 Vitexin
3 Isovitexin
1 Mung Bean Sprouts
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:462  Target#:953  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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