CaMKII Cancer Research Results

CaMKII , Calcium/Calmodulin-dependent Protein Kinase II: Click to Expand ⟱
Source:
Type:
CaMKII, short for Calcium/Calmodulin-dependent Protein Kinase II, is not a single protein but rather a family of related enzymes composed of several isoforms.
Breakdown:
CaMKII Isoforms:4 genes encoding the major isoforms: α(alpha), β(beta), γ(gamma), and δ(delta). CaMKIIα and CaMKIIβ are abundant in neuronal tissue, while CaMKIIδ is more prevalent in the heart and other non-neuronal tissues.

-Overexpression or hyperactivation of CaMKII has been linked in some studies to enhanced cell cycle progression and resistance to apoptosis, both of which are features of more aggressive tumors.
-In some cancers, upregulation or increased activity of CaMKII has been associated with poor clinical outcomes, including lower overall survival or higher recurrence rates.
Scientific Papers found: Click to Expand⟱
5536- BBM,    Regulation of Cell-Signaling Pathways by Berbamine in Different Cancers
- Review, Var, NA
JAK↝, STAT3↓, p‑CaMKII ↓, TGF-β↑, Smad1↑, ChemoSen↑, RadioS↑, TumCI↓, TumCMig↓, ROS↑, NRF2↓, SOD2↓, GPx1↓, HO-1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GPx1↓, 1,   HO-1↓, 1,   NRF2↓, 1,   ROS↑, 1,   SOD2↓, 1,  

Kinase & Signal Transduction ⓘ

p‑CaMKII ↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1,  

Migration ⓘ

Smad1↑, 1,   TGF-β↑, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Immune & Inflammatory Signaling ⓘ

JAK↝, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   RadioS↑, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CaMKII , Calcium/Calmodulin-dependent Protein Kinase II
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1142  State#:1  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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