IGF-1R Cancer Research Results

IGF-1R, insulin-like growth factor-1 receptor: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Also IGF1R
A link between elevated IGF levels and the development of solid tumors, such as breast, colon, and prostate cancer. Gene amplification of IGF1R, which encodes insulin-like growth factor 1 receptor, is a frequent event across cancer types. Upregulation of IGF1R protein expression in tumor samples and serum in NSCLC patients. Upregulation of IGF-IR signaling can help cancer cells resist anoikis by inhibiting p53 and p21 activation.
Many cancers, including breast, prostate, lung, and colorectal cancers, have been found to exhibit overexpression of IGF-1R. This overexpression can contribute to increased cell proliferation and survival, promoting tumor growth.
Scientific Papers found: Click to Expand⟱
1574- Citrate,    Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway
- in-vitro, Lung, A549 - in-vitro, Melanoma, WM983B - in-vivo, NA, NA
TumCG↓, eff↑, T-Cell↑, p‑IGF-1R↓, p‑Akt↓, PTEN↑, p‑eIF2α↑, OCR↓, ROS↓, ECAR∅, IL1↑, TNF-α↑, IL10↑, IGF-1R↓, eIF2α↑, PTEN↑, TCA↓, Glycolysis↓, selectivity↑, *toxicity∅, Dose∅,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↓, 1,  

Mitochondria & Bioenergetics ⓘ

OCR↓, 1,  

Core Metabolism/Glycolysis ⓘ

ECAR∅, 1,   Glycolysis↓, 1,   TCA↓, 1,  

Cell Death ⓘ

p‑Akt↓, 1,  

Protein Folding & ER Stress ⓘ

eIF2α↑, 1,   p‑eIF2α↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1R↓, 1,   p‑IGF-1R↓, 1,   PTEN↑, 2,   TumCG↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1↑, 1,   IL10↑, 1,   T-Cell↑, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,   eff↑, 1,   selectivity↑, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 1

Scientific Paper Hit Count for: IGF-1R, insulin-like growth factor-1 receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:155  State#:1  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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