FcεRI Cancer Research Results

FcεRI, High-Affinity Immunoglobulin E Receptor: Click to Expand ⟱
Source:
Type:

FcεRI - High-Affinity Immunoglobulin E Receptor

Abbreviation: FcεRI, Fc epsilon RI

Canonical IgE-Binding Subunit: FCER1A / FcεRIα

Type: High-affinity IgE receptor / immune-cell activation receptor

Function: FcεRI is the high-affinity receptor for immunoglobulin E (IgE) and is expressed prominently on mast cells and basophils, with expression also occurring on selected antigen-presenting cells. IgE binds the FcεRIα subunit, sensitizing the cell to specific allergens. Allergen-mediated cross-linking of FcεRI-bound IgE activates intracellular signaling involving Lyn, Fyn, Syk, PLCγ, PI3K, calcium signaling, and NF-κB, leading to mast-cell or basophil degranulation and production of lipid mediators and cytokines.

Asthma: ↑ Increased FcεRI expression and/or activation contributes strongly to allergic asthma. Elevated IgE stabilizes FcεRI on the surface of mast cells and basophils, increasing sensitivity to allergens. Allergen-induced FcεRI activation causes release of histamine, tryptase, leukotrienes including LTC4, prostaglandin D2, cytokines, and chemokines, promoting bronchoconstriction, mucus secretion, airway inflammation, airway hyperresponsiveness, and remodeling. Reduced FcεRI signaling is generally favorable in allergic asthma.

Favorable Direction in Asthma: ↓ FcεRI expression or activation reduces IgE-mediated mast-cell and basophil activation and allergic airway inflammation.
Scientific Papers found: Click to Expand⟱
7931- H2,    Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells
- in-vitro, Asthma, NA
*p‑FcεRI↓, *NADPH↓, *H2O2↓, *Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

p‑FcεRI↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

H2O2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

NADPH↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  
Total Targets: 4

Scientific Paper Hit Count for: FcεRI, High-Affinity Immunoglobulin E Receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1738  State#:1  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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