NF-kB Cancer Research Results

NF-kB, Nuclear factor kappa B: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
NF-kB signaling
Nuclear factor kappa B (NF-κB) is a transcription factor that plays a crucial role in regulating immune response, inflammation, cell proliferation, and survival.
NF-κB is often found to be constitutively active in many types of cancer cells. This persistent activation can promote tumorigenesis by enhancing cell survival, proliferation, and metastasis.
Scientific Papers found: Click to Expand⟱
3864- ACNs,    Anthocyanins Potentially Contribute to Defense against Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *Aβ↓, *ROS↓, *cognitive↑, *APP↓, *BBB↑, *Ca+2↓, *ATP↑, *BACE↓, *p‑NF-kB↓, *TNF-α↓, *iNOS↓,
3549- ALA,    Important roles of linoleic acid and α-linolenic acid in regulating cognitive impairment and neuropsychiatric issues in metabolic-related dementia
- Review, AD, NA
*Inflam↓, *other↝, *other↝, *neuroP↑, *BioAv↝, *adiP↑, *BBB↑, *Casp6↓, *Casp9↓, *TNF-α↓, *IL6↓, *IL1β↓, *ROS↓, *NO↓, *iNOS↓, *COX2↓, *JNK↓, *p‑NF-kB↓, *Aβ↓, *BP↓, *memory↑, *cAMP↑, *ERK↑, *Akt↑, cognitive?,
1181- Ash,    Withaferin A inhibits Epithelial to Mesenchymal Transition in Non-Small Cell Lung Cancer Cells
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCMig↓, TumCI↓, EMT↓, p‑SMAD2↓, p‑SMAD3↓, p‑NF-kB↓,
1242- BBM,    Berbamine Exerts Anti-Inflammatory Effects via Inhibition of NF-κB and MAPK Signaling Pathways
- in-vivo, Nor, NA
*Macrophages↓, *Neut↓, *p‑NF-kB↓, *p‑MAPK↓, *p‑JNK↓, *p‑ERK↓,
2777- Bos,    Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage
- in-vitro, IBD, NA
*p‑NF-kB↓, *ROS↓, Inflam↓,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
1620- EA,  Rad,    Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study
- in-vitro, Liver, HepG2
ROS↑, P53↑, TumCCA↑, IL6↓, COX2↓, TNF-α↓, MMP↓, angioG↓, MMP9↓, BAX↑, Casp3↑, Apoptosis↑, RadioS↑, TBARS↑, GSH↓, Bax:Bcl2↑, p‑NF-kB↓, p‑STAT3↓,
1116- GI,    6-Shogaol Inhibits the Cell Migration of Colon Cancer by Suppressing the EMT Process Through the IKKβ/NF-κB/Snail Pathway
- in-vitro, Colon, Caco-2 - in-vitro, CRC, HCT116
TumCG↓, Apoptosis↑, TumCMig↓, MMP2↓, N-cadherin↓, IKKα↓, p‑NF-kB↓, Snail↓, VEGF↓,
4293- LT,    Regulatory Role of NF-κB on HDAC2 and Tau Hyperphosphorylation in Diabetic Encephalopathy and the Therapeutic Potential of Luteolin
- in-vivo, Diabetic, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *p‑mTOR↓, *p‑NF-kB↓, *HDAC2↓, *BDNF↑, *other↓, *p‑tau↓,
1995- PTL,    The protective effect of parthenolide in an in vitro model of Parkinson's disease through its regulation of nuclear factor-kappa B and oxidative stress
- in-vitro, Park, SH-SY5Y
*Apoptosis↓, *ROS↓, *BAX↓, *NF-kB↓, *P53↓, *p‑NF-kB↓,
1489- RES,    Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer
- Review, Var, NA
RadioS↑, ChemoSen↑, *BioAv↓, *BioAv↑, Ferroptosis↑, lipid-P↑, xCT↓, GPx4↓, *BioAv↑, COX2↓, cycD1/CCND1↓, FasL↓, FOXP3↓, HLA↑, p‑NF-kB↓, BAX↑, Bcl-2↓, MALAT1↓,
2332- RES,    Resveratrol’s Anti-Cancer Effects through the Modulation of Tumor Glucose Metabolism
- Review, Var, NA
Glycolysis↓, GLUT1↓, PFK1↓, Hif1a↓, ROS↑, PDH↑, AMPK↑, TumCG↓, TumCI↓, TumCP↓, p‑NF-kB↓, SIRT1↑, SIRT3↑, LDH↓, PI3K↓, mTOR↓, PKM2↓, R5P↝, G6PD↓, TKT↝, talin↓, HK2↓, GRP78/BiP↑, GlucoseCon↓, ER Stress↑, Warburg↓, PFK↓,
3012- RosA,  Rad,    Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROSMYPT1TGFβ1 Signaling Via miR-19b-3p
- in-vitro, Nor, IMR90
*Inflam↓, *ROS↓, *p‑NF-kB↓, *Rho↓, *ROCK1↓, *radioP↑, *MCP1↓, *RANTES↓, *ICAM-1↓, *PGC1A↑, *NOX4↓, *Dose↝,
2211- SK,    Shikonin mitigates ovariectomy-induced bone loss and RANKL-induced osteoclastogenesis via TRAF6-mediated signaling pathways
- in-vivo, ostP, NA
*BMD↑, *p‑NF-kB↓, *p‑p50↓, *p‑p65↓, *p‑ERK↓, *p‑cJun↓, *p‑p38↓,
3921- VitD3,  RES,    Vitamin D Combined with Resveratrol Prevents Cognitive Decline in SAMP8 Mice
- in-vivo, AD, NA
*cognitive↑, *Aβ↓, *BACE↓, *p‑tau↓, *p‑CREB↑, *p‑NF-kB↓, *neuroP↑,

Showing Research Papers: 1 to 15 of 15

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   lipid-P↑, 1,   ROS↑, 3,   SIRT3↑, 1,   TBARS↑, 1,   TKT↝, 1,   xCT↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   mitResp↑, 1,   MMP↓, 2,   MPT↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   G6PD↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   LDH↓, 1,   PDH↑, 1,   PFK↓, 1,   PFK1↓, 1,   PKM2↓, 1,   R5P↝, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 3,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   FasL↓, 1,   Ferroptosis↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 2,   GRP78/BiP↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   EMT↓, 2,   mTOR↓, 1,   PI3K↓, 2,   p‑STAT3↓, 1,   TumCG↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

Ca+2↑, 1,   HLA↑, 1,   MALAT1↓, 1,   MMP2↓, 2,   MMP9↓, 2,   N-cadherin↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   Snail↓, 1,   talin↓, 1,   TumCI↓, 4,   TumCMig↓, 4,   TumCP↓, 2,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   FOXP3↓, 1,   IKKα↓, 1,   IL6↓, 1,   Inflam↓, 2,   p‑NF-kB↓, 6,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   RadioS↑, 3,  

Clinical Biomarkers ⓘ

IL6↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

chemoPv↑, 1,   cognitive?, 1,   Risk↓, 1,   toxicity↓, 1,   toxicity↝, 1,  
Total Targets: 83

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   NOX4↓, 1,   ROS↓, 5,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,  

Core Metabolism/Glycolysis ⓘ

adiP↑, 1,   cAMP↑, 1,   p‑CREB↑, 1,   PGC1A↑, 1,  

Cell Death ⓘ

Akt↑, 1,   Apoptosis↓, 1,   BAX↓, 1,   Casp6↓, 1,   Casp9↓, 1,   iNOS↓, 2,   JNK↓, 1,   p‑JNK↓, 1,   p‑MAPK↓, 1,   p‑p38↓, 1,  

Transcription & Epigenetics ⓘ

p‑cJun↓, 1,   other↓, 1,   other↝, 2,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1,   p‑ERK↓, 2,   HDAC2↓, 1,   p‑mTOR↓, 1,  

Migration ⓘ

APP↓, 1,   Ca+2↓, 1,   Rho↓, 1,   ROCK1↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   ICAM-1↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 3,   Macrophages↓, 1,   MCP1↓, 1,   Neut↓, 1,   NF-kB↓, 1,   p‑NF-kB↓, 9,   p‑p50↓, 1,   p‑p65↓, 1,   RANTES↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

BDNF↑, 1,   p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 3,   BACE↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 2,   BioAv↝, 1,   Dose↝, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BP↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

cognitive↑, 3,   memory↑, 1,   neuroP↑, 3,   radioP↑, 1,  
Total Targets: 61

Scientific Paper Hit Count for: NF-kB, Nuclear factor kappa B
3 Resveratrol
2 Radiotherapy/Radiation
1 Anthocyanins
1 Alpha-Lipoic-Acid
1 Ashwagandha(Withaferin A)
1 Berbamine
1 Boswellia (frankincense)
1 Celecoxib
1 Ellagic acid
1 Ginger/6-Shogaol/Gingerol
1 Luteolin
1 Parthenolide
1 Rosmarinic acid
1 Shikonin
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:214  State#:1  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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