STAT5 Cancer Research Results

STAT5, Signal transducer and activator of transcription 5: Click to Expand ⟱
Source:
Type:
Signal Transducer and Activator of Transcription 5 (STAT5) is a transcription factor that plays a crucial role in various cellular processes, including cell growth, differentiation, and survival.
STAT5 can function as an oncogene in certain types of cancer. Its persistent activation has been associated with the development and progression of various malignancies, including breast cancer, prostate cancer, and hematological cancers like leukemia and lymphoma.
High STAT5 expression has been associated with poor prognosis and increased metastasis.
Scientific Papers found: Click to Expand⟱
573- ART/DHA,    Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model
- vitro+vivo, NA, NA
p‑p38↓, p‑ERK↓, p‑CREB↓, p‑Chk2↓, p‑STAT5↓, p‑RSK↓, SOCS1↑, Apoptosis↑, Casp3↑,
1070- IVM,    Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation
- vitro+vivo, GBM, NA
TumCG↓, LC3II↑, p62↓, ATP↓, Pyruv↓, GlucoseCon↑, HK2↓, PFK1↓, GLUT4↓, Glycolysis↓, JAK2↓, p‑STAT3↓, p‑STAT5↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

p‑CREB↓, 1,   GlucoseCon↑, 1,   Glycolysis↓, 1,   HK2↓, 1,   PFK1↓, 1,   Pyruv↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   Casp3↑, 1,   p‑Chk2↓, 1,   p‑p38↓, 1,   p‑RSK↓, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   p62↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   p‑STAT3↓, 1,   p‑STAT5↓, 2,   TumCG↓, 1,  

Barriers & Transport ⓘ

GLUT4↓, 1,  

Immune & Inflammatory Signaling ⓘ

JAK2↓, 1,   SOCS1↑, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: STAT5, Signal transducer and activator of transcription 5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:372  State#:1  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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