Casp1 Cancer Research Results

Casp1, Caspase-1: Click to Expand ⟱
Source:
Type:
Also known as ICE (Interleukin-1 beta Convertase).
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Caspase-1 may have both tumorigenic or antitumorigenic effects on cancer development and progression, but it depends on the type of inflammasome, methodology, and cancer.
Caspase-1:
Role: Involved in inflammation and pyroptosis.
Cancers: Elevated in certain cancers, including colorectal cancer and pancreatic cancer.
Prognosis: High levels may be associated with a more aggressive tumor phenotype.
Scientific Papers found: Click to Expand⟱
3471- MF,    The prevention effect of pulsed electromagnetic fields treatment on senile osteoporosis in vivo via improving the inflammatory bone microenvironment
- in-vivo, Nor, NA
*BMD↑, *NLRP3↓, *proCasp1↓, *cl‑Casp1↓, *IL1β↓, *GSDMD↓,
2972- PL,    Piperlongumine Is an NLRP3 Inhibitor With Anti-inflammatory Activity
- in-vitro, AML, THP1
NLRP3↓, IL1β↓, LDH↓, cl‑Casp1↓, Inflam↓,
6422- QC,    Quercetin Protects Ethanol-Induced Hepatocyte Pyroptosis via Scavenging Mitochondrial ROS and Promoting PGC-1α-Regulated Mitochondrial Homeostasis in L02 Cells
- in-vitro, Alcohol, L02
*mt-ROS↓, *lipid-P↓, *MMP↑, *mtDam↓, *NLRP3↓, *ASC↓, *cl‑Casp1↓, *IL18↓, *IL1β↓, *GSDMD↓, *Pyro↓, *CYP2E1↓, *MFN1↓, *MFN2↓, *OPA1↓, *DRP1/DNM1L↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

LDH↓, 1,  

Cell Death(tgid=5) ⓘ

cl‑Casp1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   Inflam↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

LDH↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

CYP2E1↓, 1,   lipid-P↓, 1,   MFN1↓, 1,   MFN2↓, 1,   OPA1↓, 1,   mt-ROS↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↑, 1,   MMP↑, 1,   mtDam↓, 1,  

Cell Death(tgid=5) ⓘ

cl‑Casp1↓, 2,   proCasp1↓, 1,   GSDMD↓, 2,   Pyro↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   IL18↓, 1,   IL1β↓, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,  
Total Targets: 18

Scientific Paper Hit Count for: Casp1, Caspase-1
1 Magnetic Fields
1 Piperlongumine
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:41  State#:2  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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